Month: April 2022

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 15227-42-6, is researched, Molecular C10H10Cl2N2Pt, about The effects of single administration of an antitumor platinum compound on ornithine decarboxylase activity in certain tissues of mice bearing L1210 leukemia, the main research direction is antitumor platinum compound ornithine decarboxylase; leukemia platinum compound ornithine decarboxylase.Safety of cis-Dichlorobis(pyridine)platinum(II).

A single dose of cis-dichloro(dipyridine)platinum(II) [15227-42-6], when given to mice bearing 1-day-old L1210 leukemia, suppressed the increase of spleen and liver ornithine decarboxylase (ODC) [9024-60-6] activity which occurs concomitantly with development of the leukemia. The inhibition of ODC, the rate-limiting enzyme in polyamine synthesis, appeared to correlate with the prolonged chemotherapeutic efficacy of a single dose of the platinum complex. These observations suggest an addnl. mechanism by which platinum complexes express their antitumor actions and, in addition, support the view that polyamine synthesis and excretion patterns can be used as predictors of chemotherapeutic response.

The article 《The effects of single administration of an antitumor platinum compound on ornithine decarboxylase activity in certain tissues of mice bearing L1210 leukemia》 also mentions many details about this compound(15227-42-6)Safety of cis-Dichlorobis(pyridine)platinum(II), you can pay attention to it, because details determine success or failure

Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 693-67-4, is researched, SMILESS is CCCCCCCCCCCBr, Molecular C11H23BrJournal, Applied Organometallic Chemistry called Mn(II) and Zn(II) complexes of a benzimidazole ligand having undecyl chains: Crystal structures, photophysical and thermal properties, Author is Kirpik, Hilal; Kose, Muhammet, the main research direction is manganese zinc undecyl pyridyl benzimidazole complex preparation crystal structure; luminescence manganese zinc undecyl pyridyl benzimidazole complex; thermal property zinc undecyl pyridyl benzimidazole complex.Quality Control of 1-Bromoundecane.

A new tridentate benzimidazole ligand (L-C11) containing undecyl chains and its Mn(II) and Zn(II) complexes were synthesized and characterized by spectroscopic and anal. methods. Mol. structures of complexes [Mn(L-C11)Cl2] and [Zn(L-C11)Cl2] were evaluated by x-ray diffraction studies. The x-ray data showed metal ions in both complexes are five-coordinate with distorted square pyramidal geometry around the metal centers. The undecyl chains in the structure of the complexes are aligned in an interdigitated manner (head to tail) forming a non-polar domain. The aggregation properties of the ligand and its complexes were studied by UV-visible absorption and emission spectroscopies in DMF-water mixtures The emission spectral data revealed that the compounds showed aggregation induced quenching (AIQ) in DMF-water solutions Moreover, thermal properties of the compounds were studied by TG, DTG and DSC anal.

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Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Electric Literature of C11H23Br. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 1-Bromoundecane, is researched, Molecular C11H23Br, CAS is 693-67-4, about Charge Transportation and Chirality in Liquid Crystalline Helical Network Phases of Achiral BTBT-Derived Polycatenar Molecules. Author is Kwon, Ohjin; Cai, Xiaoqian; Qu, Wentao; Liu, Feng; Szydlowska, Jadwiga; Gorecka, Ewa; Han, Moon Jong; Yoon, Dong Ki; Poppe, Silvio; Tschierske, Carsten.

First examples of multichain (polycatenar) compounds, based on the π-conjugated [1]benzothieno[3,2-b]benzothiophene unit (I, R = alkyl homologs) are designed, synthesized, and their soft self-assembly and charge carrier mobility are investigated. These compounds, terminated by the new fan-shaped 2-brominated 3,4,5-trialkoxybenzoate moiety, form bicontinuous cubic liquid crystalline (LC) phases with helical network structure over extremely wide temperature ranges (>200 K), including ambient temperature Compounds with short chains show an achiral cubic phase with the double network, which upon increasing the chain length, is at first replaced by a tetragonal 3D phase and then by a mirror symmetry is broken triple network cubic phase. In the networks, the capability of bypassing defects provides enhanced charge carrier mobility compared to imperfectly aligned columnar phases, and the charge transportation is non-dispersive, as only rarely observed for LC materials. At the transition to a semicrystalline helical network phase, the conductivity is further enhanced by almost one order of magnitude. In addition, a mirror symmetry broken isotropic liquid phase is formed beside the 3D phases, which upon chain elongation is removed and replaced by a hexagonal columnar LC phase.

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Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Challa, Prathap; Venkata Rao, M.; Nagaiah, P.; Nagu, A.; David Raju, B.; Rama Rao, K. S. published an article about the compound: Picolinamide( cas:1452-77-3,SMILESS:O=C(N)C1=NC=CC=C1 ).Reference of Picolinamide. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:1452-77-3) through the article.

The present work is aimed to produce di-Me carbonate by coupling of CH3OH and CO2 with 2-cyanopyridine over ZnO-CeO2 catalysts prepared by co-precipitation method. These catalysts were characterized by XRD, TEM, UV-Vis DRS, BET surface area, CO2 and NH3-TPD techniques and applied for the titled reaction. Among the investigated catalysts 10ZnO-90CeO2 catalyst with CeO2 crystallite size 8.0 nm exhibited 96% conversion of methanol with 99% selectivity to di-Me carbonate. The superior catalytic activity is a unified effect of crystalline size of CeO2 and presence of an optimum number of acidic and basic sites. This protocol offers enhanced conversion of methanol with the simultaneous conversion of 2-cyanopyridine into 2-picolinamide by removing water mols. formed in the reaction.

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Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Name: 4-Chloro-4′-ethynyl-1,1′-biphenyl. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 4-Chloro-4′-ethynyl-1,1′-biphenyl, is researched, Molecular C14H9Cl, CAS is 57399-11-8, about Synthesis and Antiplasmodial Activity of New Indolone N-Oxide Derivatives. Author is Nepveu, Francoise; Kim, Sothea; Boyer, Jeremie; Chatriant, Olivier; Ibrahim, Hany; Reybier, Karine; Monje, Marie-Carmen; Chevalley, Severine; Perio, Pierre; Lajoie, Barbora H.; Bouajila, Jalloul; Deharo, Eric; Sauvain, Michel; Tahar, Rachida; Basco, Leonardo; Pantaleo, Antonella; Turini, Francesco; Arese, Paolo; Valentin, Alexis; Thompson, Eloise; Vivas, Livia; Petit, Serge; Nallet, Jean-Pierre.

A series of 66 new indolone-N-oxide derivatives, e.g. I, was synthesized with three different methods. Compounds were evaluated for in vitro activity against CQ-sensitive (3D7), CQ-resistant (FcB1), and CQ and pyrimethamine cross-resistant (K1) strains of Plasmodium falciparum (P.f.), as well as for cytotoxic concentration (CC50) on MCF7 and KB human tumor cell lines. Compound II (5-methoxy-indolone-N-oxide analog) had the most potent antiplasmodial activity in vitro (<3 nM on FcB1 and = 1.7 nM on 3D7) with a very satisfactory selectivity index (CC50 MCF7/IC50 FcB1: 14623; CC50 KB/IC50 3D7: 198823). In in vivo experiments, compound I (dioxymethylene derivatives of the indolone-N-oxide) showed the best antiplasmodial activity against Plasmodium berghei, 62% inhibition of the parasitemia at 30 mg/kg/day. After consulting a lot of data, we found that this compound(57399-11-8)Name: 4-Chloro-4′-ethynyl-1,1′-biphenyl can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 1452-77-3, is researched, SMILESS is O=C(N)C1=NC=CC=C1, Molecular C6H6N2OJournal, Asian Journal of Organic Chemistry called Picolinamide-Based Iridium Catalysts for Aqueous Formic Acid Dehydrogenation: Increase in Electron Density of Amide N through Substituents, Author is Guo, Jian; Yin, Chengkai; Li, Maoliang; Zhong, Dulin; Zhang, Yuguan; Li, Xiaobin; Wang, Yilin; Yao, Hong; Qi, Tiangui, the main research direction is formic acid picolinamide iridium catalyst dehydrogenation.Application In Synthesis of Picolinamide.

Formic acid (FA) is considered to be a potential hydrogen storage material. Homogeneous catalysts are desired, which decompose aqueous FA into H2 and CO2 without addition of organic additives as they can contaminate the generated gas mixture We report a new series of Cp*Ir (Cp*=pentamethylcyclopentadienyl) catalysts featuring picolinamide-based ligands for efficient H2 generation from FA solution Among them in-situ generated catalyst from [Cp*Ir(H2O)3]SO4 and picolinohydroxamic acid (L3) achieved a high turnover frequency (TOF) of 90625 h-1 at 80 °C in 0.9 M FA solution and a turnover number (TON) of 120520 at 80 °C in a recycle experiment The substituent effect of amide N atom was discussed and a plausible mechanism was proposed based on the exptl. results.

After consulting a lot of data, we found that this compound(1452-77-3)Application In Synthesis of Picolinamide can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Journal of Organometallic Chemistry called Appraisal of Ruthenium(II) complexes of (4-phenoxyphenylazo) ligands for the synthesis of primary amides by dint of hydroxylamine hydrochloride and aldehydes, Author is Vinoth, Govindasamy; Indira, Sekar; Bharathi, Madheswaran; Sounthararajan, Muniyan; Sakthi, Dharmalingam; Bharathi, Kuppannan Shanmuga, which mentions a compound: 1452-77-3, SMILESS is O=C(N)C1=NC=CC=C1, Molecular C6H6N2O, Related Products of 1452-77-3.

A new family of O, N donor-functionalized (4-phenoxyphenylazo)-2-naphthol/4-substituted phenol-based ligands (HL1-HL4) has been synthesized. The prepared ligands were successfully utilized for the access of a series of ruthenium(II) carbonyl complexes of the type [Ru(L)Cl(CO)(EPh3)3] (E = phosphine/arsine), (L = 1-(4-phenoxyphenylazo)-2-naphthol (HL1), 2-(4-phenoxyphenylazo)-4-chlorophenol (HL2), 2-(4-phenoxyphenylazo)-4-methylphenol (HL3) and 2-(4-phenoxyphenylazo)-4-methoxyphenol (HL4)). All of the ruthenium(II) carbonyl complexes and ligands have been fully characterized by FT-IR, UV-visible, 1H NMR, 31P NMR, mass spectrometry and CHN anal. The ligands have been analyzed by 13C NMR. The UV-visible spectroscopic study reveals that both the ligands and Ru(II) complexes exhibit excellent charge transfer transitions. This is the basic criteria for the oxidative amidation reaction, which is an influential strategy for the transformation of oxygenated organic compounds to the profitable amides. However, this catalytic process makes more impact on the application of new divalent ruthenium(II) azo compounds as catalyst in a single-pot conversion of aldehydes to amides in the presence of NaHCO3.

After consulting a lot of data, we found that this compound(1452-77-3)Related Products of 1452-77-3 can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Name: cis-Dichlorobis(pyridine)platinum(II). The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: cis-Dichlorobis(pyridine)platinum(II), is researched, Molecular C10H10Cl2N2Pt, CAS is 15227-42-6, about Research at ICI Central Petrochemical and Polymer Laboratory, Runcorn Heath. NQR spectrometry. Author is Fryer, C. W..

The use of 35Cl nuclear quadrupole resonance (NQR) in the study of transition metal compounds is discussed. In the NQR spectra of cis-and trans-L2PtCl2, the difference in the 35Cl NQR frequencies (νtrans-νcis) increases 0.95, 1.98, 3.1 MHz, for L = Me2NH, pyridine, and Bu3P, resp. Frequency variation is greater among the trans compounds Charge donating properties of L to Pt have a larger effect on the ν 35 Cl attached to the Pt than does the weakening influence of L. The 35Clν for bridging Cl in trans-L2Pt2Cl4 and trans-L2Pd2Cl4 are much lower (at 15.46 and 12.84 MHz, resp.) than the frequencies of the terminal Cl(at 22.36 and 19.56 MHz). This difference can be used in studying cluster compounds

After consulting a lot of data, we found that this compound(15227-42-6)Name: cis-Dichlorobis(pyridine)platinum(II) can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Journal of Medicinal Chemistry called Discovery of SY-5609: A Selective, Noncovalent Inhibitor of CDK7, Author is Marineau, Jason J.; Hamman, Kristin B.; Hu, Shanhu; Alnemy, Sydney; Mihalich, Janessa; Kabro, Anzhelika; Whitmore, Kenneth Matthew; Winter, Dana K.; Roy, Stephanie; Ciblat, Stephane; Ke, Nan; Savinainen, Anneli; Wilsily, Ashraf; Malojcic, Goran; Zahler, Robert; Schmidt, Darby; Bradley, Michael J.; Waters, Nigel J.; Chuaqui, Claudio, which mentions a compound: 882562-40-5, SMILESS is ClC1=NC(C2=CN(C3=C2C=CC=C3)S(=O)(=O)C2=CC=CC=C2)=C(Cl)C=N1, Molecular C18H11Cl2N3O2S, Related Products of 882562-40-5.

CDK7 has emerged as an exciting target in oncol. due to its roles in two important processes that are misregulated in cancer cells: cell cycle and transcription. This report describes the discovery of SY-5609, a highly potent (sub-nM CDK7 Kd) and selective, orally available inhibitor of CDK7 that entered the clinic in 2020 (ClinicalTrials.gov Identifier: NCT04247126). Structure-based design was leveraged to obtain high selectivity (>4000-times the closest off target) and slow off-rate binding kinetics desirable for potent cellular activity. Finally, incorporation of a phosphine oxide as an atypical hydrogen bond acceptor helped provide the required potency and metabolic stability. The development candidate SY-5609 displays potent inhibition of CDK7 in cells and demonstrates strong efficacy in mouse xenograft models when dosed as low as 2 mg/kg.

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Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

HPLC of Formula: 114362-20-8. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 4-Amino-2-(tert-butyl)pyrimidine, is researched, Molecular C8H13N3, CAS is 114362-20-8, about σ-Adduct formation between amines and liquid ammonia. Part 47. On the Chichibabin amination of pyrimidine and N-alkylpyrimidinium salts using liquid ammonia/potassium permanganate. Author is Buurman, Dick J.; Van der Plas, Henk C..

4-Aminopyrimidines I (R1 = C1-4 alkyl) and iminodihydropyrimidines II (R2 = Et, CHMe2) were prepared 2-Alkylpyrimidines were treated with KNH2-NH3-KMnO4 to give I. The reaction of 1,2-diethylpyrimidinium fluoroborate with NH3-KMnO4 gave II (R2 = Et).

After consulting a lot of data, we found that this compound(114362-20-8)HPLC of Formula: 114362-20-8 can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem