Month: April 2022

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Even-Odd Alkyl Chain-Length Alternation Regulates Oligothiophene Crystal Structure, published in 2019-09-10, which mentions a compound: 693-67-4, Name is 1-Bromoundecane, Molecular C11H23Br, Safety of 1-Bromoundecane.

Alkyl chains of varied length and steric bulk are generally appended to π-conjugated chromophores to increase solubility These alkyl chains also regulate many aspects of the solid-state packing and, in turn, resultant electronic and optical properties of organic semiconductors, yet there remains little understanding as to how these moieties govern such characteristics. Here, we report on a series of (2,5-bis(3-alkylthiophen-2-yl) thieno[3,2-b]thiophenes) (BTTT) monomers where the single-crystal packing configurations and m.ps. alternate as a function of whether the alkyl side chains have an even or odd number of carbon atoms. When the alkyl chains contain an even number of carbon atoms, the mols. predominantly crystallize with the BTTT units of the stacked lamellae aligned in the same direction. In contrast, when the number of carbon atoms is odd, alternating lamellae are twisted with respect to their neighbors, i.e. the BTTT moieties in one layer are aligned in an orthogonal-like fashion to those in its neighboring lamellae, and the crystal m.ps. tend to be higher than those with the even-numbered alkyl chains. With d. functional theory calculations and geometric analyses, the variations in crystal structure and thus the differences in phys. properties are rationalized by an oscillating interlayer interaction that is a function of alkyl side chain atom count and length. This study characterizes an extreme case of an organic semiconductor crystal packing alternation to highlight the effect of even-odd assembly as an underutilized and under-reported handle for tuning the mol. packing of organic semiconductor materials.

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Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

COA of Formula: C11H23Br. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 1-Bromoundecane, is researched, Molecular C11H23Br, CAS is 693-67-4, about Polar functional group-containing glycolipid CD1d ligands modulate cytokine-biasing responses and prevent experimental colitis.

The MHC class I-like mol. CD1d is a nonpolymorphic antigen-presenting glycoprotein, and its ligands include glycolipids, such as α-GalCer. The complexes between CD1d and ligands activate natural killer T cells by T cell receptor recognition, leading to the secretion of various cytokines (IFN-γ, IL-4, IL-17A, etc.). Herein, we report structure-activity relationship studies of α-GalCer derivatives containing various functional groups in their lipid acyl chains. Several derivatives have been identified as potent CD1d ligands displaying higher cytokine induction levels and/or unique cytokine polarization. The studies also indicated that flexibility of the lipid moiety can affect the binding affinity, the total cytokine production level and/or cytokine biasing. Based on our immunol. evaluation and investigation of physicochem. properties, we chose bisamide- and Bz amide-containing derivatives 2 and 3, and evaluated their in vivo efficacy in a DSS-induced model of ulcerative colitis. The derivative 3 that exhibits Th2- and Th17-biasing responses, demonstrated significant protective effects against intestinal inflammation in the DSS-induced model, after a single i.p. injection.

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Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Name: cis-Dichlorobis(pyridine)platinum(II). The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: cis-Dichlorobis(pyridine)platinum(II), is researched, Molecular C10H10Cl2N2Pt, CAS is 15227-42-6, about Effect of catalyst structure on the reaction of α-methylstyrene with 1,1,3,3-tetramethyldisiloxane. Author is Vekki, D. A.; Skvortsov, N. K..

Reaction of α-methylstyrene with 1,1,3,3-tetramethyldisiloxane in the presence of the complexes of Pt(II), Pd(II) and Rh(I) is explored. In the presence of Pt catalyst, hydrosilylation of α-methylstyrene occurs predominantly giving β-adduct, while on Pd catalysts proceeds reduction of α-methylstyrene and on Rh catalysts both processes take place. In the reaction mixture proceeds disproportion and dehydro-condensation of 1,1,3,3-tetramethyldisiloxane that gives long chain linear and cyclic siloxanes HMe2Si(OSiMe2)nH and (-OSiMe2-)m (n = 2-6, m = 3-7), resp. Platinum catalysts promotes formation of linear siloxanes, while both Rh and Pd catalysts afford linear and cyclic siloxanes as well. Structure of intermediate metallo-complexes was studied.

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Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Synthetic Route of C10H10Cl2N2Pt. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: cis-Dichlorobis(pyridine)platinum(II), is researched, Molecular C10H10Cl2N2Pt, CAS is 15227-42-6, about Redistribution of ligands in [Rh(CO)A(PPh3)2][Pt(py)Cl3].

[Rh(CO)A(PPh3)2][Pt(py)Cl3].DMF (I; A = py, 4-picoline (pic), 2,2′-bipyridine (bpy), 1,10-phenanthroline (phen)) were prepared by the reaction of [Rh(CO)A(PPh3)2]NO3 with K[Pt(py)Cl3] in DMF. For I (A = py, pic) at room temperature in DMF, Me2CO, CHCl3 or C6H6 after 15-30 min., redistribution of ligands occurred with the formation of Rh(CO)(PPh3)2Cl and cis-Pt(py)ACl2. I (A = bpy, phen) are stable in solution

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Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: cis-Dichlorobis(pyridine)platinum(II), is researched, Molecular C10H10Cl2N2Pt, CAS is 15227-42-6, about cis-Bis(pyridine)platinum(II) organoamides with unexpected growth inhibition properties and antitumor activity.Category: tetrahydroisoquinoline.

The platinum(II) organoamides [Pt(NRCH2)2L2] (L = pyridine (py), R = p-HC6F4, C6F5, p-IC6F4, p-ClC6F4, p-C6F5C6F4; L = 4-methylpyridine, R = p-HC6F4) and [Pt(NRCH2CH2NR’)(py)2] (R = p-HC6F4, R’ = C6F5, p-BrC6F4, or p-MeC6F4) inhibit the growth of murine L1210 leukemia cells in culture with ID50 values for continuous exposure in the range 0.6-2.7 μM. Representative complexes are also active against L1210 cells in 2-h pulse exposures, as well as against the cisplatin-resistant variant L1210/DDP and human colonic carcinoma cell lines HT 29 and BE. Three complexes [Pt(NRCH2)2L2] (R = p-HC6F4, C6F5, or p-IC6F4) have good activity (T/C ≥ 180%) against P388 leukemia in mice, and all other compounds tested are active except when R = p-C6F5C6F4, L = py. Although the mol. basis of the biol. activity of these complexes is not known, the observation of good activity for amineplatinum(II) compounds with no hydrogen substituents on the nitrogen donor atoms introduces a new factor in the anticancer behavior of platinum(II) complexes.

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Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Computed Properties of C10H10Cl2N2Pt. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: cis-Dichlorobis(pyridine)platinum(II), is researched, Molecular C10H10Cl2N2Pt, CAS is 15227-42-6, about Binding of antitumor platinum compound to cells as influenced by physical factors and pharmacologically active agents. Author is Gale, Glen R.; Morris, Carl R.; Atkins, Loretta M.; Smith, Alayne B..

Tritiated cis-dichloro(dipyridine)platinum(II) (I) [15227-42-6] bound to intact Ehrlich ascites tumor cells at 37.deg. in vitro and remained associated with the acid-insoluble fraction of the cells. The extent of binding was also increased with increasing hydrogen ion [1333-74-0] concentration in the medium. The binding was enhanced markedly at 60.deg. and the maximum number of binding sites/cell was .sim.7 billion at this temperature Of 49 chems. and drugs tested, none decreased appreciably the rate and extent of binding, whereas certain heavy metals, and compounds that compromise membrane permeability enhanced the binding. Human and bovine lymphocytes had similar binding characteristics, but bound much more I/unit of cell volume.

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Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Computed Properties of C6H6N2O. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: Picolinamide, is researched, Molecular C6H6N2O, CAS is 1452-77-3, about Aqueous-Phase Nitrile Hydration Catalyzed by an In Situ Generated Air-Stable Ruthenium Catalyst. Author is Ounkham, Whalmany L.; Weeden, Jason A.; Frost, Brian J..

RuCl2(PTA)4 (PTA=1,3,5-triaza-7-phosphaadamantane) is an active, recyclable, air-stable, aqueous-phase nitrile hydration catalyst. The development of an in situ generated aqueous-phase nitrile hydration catalyst (RuCl3·3 H2O + 6 equiv PTA) is reported. The activity of the in situ catalyst is comparable to RuCl2(PTA)4. The effects of [PTA] on the activity of the reaction were investigated: the catalytic activity, in general, increases as the pH goes up, which shows a pos. correlation with [PTA]. The pH effects were further explored for both the in situ and RuCl2(PTA)4 catalyzed reaction in phosphate buffer solutions with particular attention given to pH 6.8 buffer. Increased catalytic activity was observed at pH 6.8 vs. water for both systems with turnover frequency (TOF) up to 135 h-1 observed for RuCl2(PTA)4 and 64 h-1 for the in situ catalyst. Catalyst loading down to 0.001 mol % was examined with turnover numbers as high as 22 000 reported. Similar to the preformed catalyst, RuCl2(PTA)4, the in situ catalyst could be recycled more than five times without significant loss of activity from either water or pH 6.8 buffer.

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Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Formula: C10H10Cl2N2Pt. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: cis-Dichlorobis(pyridine)platinum(II), is researched, Molecular C10H10Cl2N2Pt, CAS is 15227-42-6, about Antitumor activity of Group VIII transition metal complexes. I. Platinum(II) complexes. Author is Cleare, Michael J.; Hoeschele, James D..

A wide variety of Pt(II) complexes were studied for antitumor activity against Sarcoma 180 in female mice. In general only neutral complexes exhibited activity, whereas charged species were inactive and relatively nontoxic. A series of complexes of the type cis-[PtA2X2] (where A2 is either 2 monodentate or 1 bidentate amine ligand and X2 is either 2 monodentate or 1 bidentate anionic ligand) were studied with A and B being systematically varied. At least 10 potentially active antitumor drugs were identified, including cis-dichlorbis(methylamine)platinum(2+) [15273-32-2], diamminepropanedioatoplatinum(2+) [38780-43-7], and (1,2-ethanediammine-N,N’)(2-methylpropanedioato)platinum(2+) [41575-97-7]. The trans isomers were inactive in comparison with active cis complexes, so the presence of cis-reactive ligands seems to be a necessary parameter for antitumor activity. Complexes with highly reactive ligands such as cis-[Pt(NH3)2 (H2O)2](NO3)2 were highly toxic. Pd(II) complexes analogous to the active Pt(II) compounds were themselves inactive.

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Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 693-67-4, is researched, SMILESS is CCCCCCCCCCCBr, Molecular C11H23BrJournal, Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov’t, Research Support, U.S. Gov’t, Non-P.H.S., Biomacromolecules called Screening Libraries of Amphiphilic Janus Dendrimers Based on Natural Phenolic Acids to Discover Monodisperse Unilamellar Dendrimersomes, Author is Buzzacchera, Irene; Xiao, Qi; Han, Hong; Rahimi, Khosrow; Li, Shangda; Kostina, Nina Yu.; Toebes, B. Jelle; Wilner, Samantha E.; Moller, Martin; Rodriguez-Emmenegger, Cesar; Baumgart, Tobias; Wilson, Daniela A.; Wilson, Christopher J.; Klein, Michael L.; Percec, Virgil, the main research direction is dendrimer dendrimersome.Quality Control of 1-Bromoundecane.

Natural, including plant, and synthetic phenolic acids are employed as building blocks for the synthesis of constitutional isomeric libraries of self-assembling dendrons and dendrimers that are the simplest examples of programmed synthetic macromols. Amphiphilic Janus dendrimers are synthesized from a diversity of building blocks including natural phenolic acids. They self-assemble in water or buffer into vesicular dendrimersomes employed as biol. membrane mimics, hybrid and synthetic cells. These dendrimersomes are predominantly uni- or multilamellar vesicles with size and polydispersity that is predicted by their primary structure. However, in numerous cases, unilamellar dendrimersomes completely free of multilamellar assemblies are desirable. Here, we report the synthesis and structural anal. of a library containing 13 amphiphilic Janus dendrimers containing linear and branched alkyl chains on their hydrophobic part. They were prepared by an optimized iterative modular synthesis starting from natural phenolic acids. Monodisperse dendrimersomes were prepared by injection and giant polydisperse by hydration. Both were structurally characterized to select the mol. design principles that provide unilamellar dendrimersomes in higher yields and shorter reaction times than under previously used reaction conditions. These dendrimersomes are expected to provide important tools for synthetic cell biol., encapsulation, and delivery.

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Tetrahydroisoquinoline – Wikipedia,
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So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Okada, Yoshio; Tani, Shohei; Yawatari, Yuko; Yagyu, Masami researched the compound: D-Alanine methylamide hydrochloride( cas:61302-99-6 ).Recommanded Product: 61302-99-6.They published the article 《Synthesis of stereoisomeric alanine containing peptide derivatives》 about this compound( cas:61302-99-6 ) in Chemical & Pharmaceutical Bulletin. Keywords: alanine peptide stereoisomer; alanylalanine bactericide. We’ll tell you more about this compound (cas:61302-99-6).

D-alanine derivatives and their stereoisomers and D-alanyl-D-alanine derivatives and their stereoisomers (R1-Ala-R2, R1-Ala-Ala-R2: R1 = PhCH2O2C, H; R2 = NHNH2, NHCH3, NHCH2CH2OH) were synthesized. All compounds obtained did not show antibacterial activity against Staphylococcus aureus, Sarcina lutea, Pseudomonas aeruginosa and Escherichia coli.

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Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem