Month: April 2022

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 1452-77-3, is researched, SMILESS is O=C(N)C1=NC=CC=C1, Molecular C6H6N2OJournal, Journal of Organometallic Chemistry called Design of organoruthenium complexes for nanoparticle functionalization, Author is Kumar, Saawan; Gallician, Guillaume; Weidener, Dennis; Sullivan, Matthew P.; Sohnel, Tilo; Hanif, Muhammad; Hartinger, Christian G., the main research direction is organoruthenium complex design nanoparticle functionalization.Related Products of 1452-77-3.

In recent years, extensive research efforts have been focused on loading metal complexes onto macromol. systems such as nanoparticles. We report a ligand with a catechol group based on a picolinamide which allows for coordination to organoruthenium moieties while the catechol group remains available for loading on nanoparticles as delivery vehicles towards tumors. All the compounds were characterized with standard anal. methods and the mol. structure of the ligand 1, and its Ru complexes 1a and 1b were determined by X-ray diffraction anal. The crystal structure of 1a and 1b showed pseudo-tetrahedral geometry of the Ru center with “”piano-stool”” conformation and 1 coordinated as an N,O-bidentate ligand, however, the latter depending on the reaction conditions employed. The Ru complexes 1a-1c were effectively loaded on magnetite nanoparticles as characterized by inductively-coupled plasma mass spectrometry (ICP-MS), transmission electron microscopy (TEM) and Fourier transform IR spectroscopy (FTIR).

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Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Determination of cis-trans isomers of amine and pyridine platinum(II) complexes by J(Pt-H) coupling constants, published in 1990, which mentions a compound: 15227-42-6, Name is cis-Dichlorobis(pyridine)platinum(II), Molecular C10H10Cl2N2Pt, Recommanded Product: cis-Dichlorobis(pyridine)platinum(II).

The coupling constants 3J(Pt-H) of Pt(Xpy)2Z2 and Pt(Xpy)(DMSO)I2 (Xpy = py and its 4-Me, 3,5-Me, 4-Cl, 4-CN, 4-HOCH2, 4-AcO derivatives; Z = Cl, I, Br, ONO2) were recorded. The 3J(Pt-H) values of the cis complexes are 42 ± 2 Hz, while those of the trans derivatives are 31.5 ± 2.5 Hz. 2J(Pt-H) of [Pt(XNH2)2Z2] (X = Me, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl; Z = Cl, I, ONO2) were recorded. The 2J(Pt-H) values of the cis complexes are 66.5 ± 1.5z, those of the trans derivatives are 58 ± 2 Hz. Measurements of Pt-H coupling constants is a rapid method of identifying the cis and the trans isomers of Pt(II) complexes.

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Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 15227-42-6, is researched, SMILESS is [Cl-][Pt+2]([N]1=CC=CC=C1)([Cl-])[N]2=CC=CC=C2, Molecular C10H10Cl2N2PtJournal, Article, Research Support, Non-U.S. Gov’t, Research Support, U.S. Gov’t, P.H.S., Cancer Research called Activation of the trans geometry in platinum antitumor complexes: a survey of the cytotoxicity of trans complexes containing planar ligands in murine L1210 and human tumor panels and studies on their mechanism of action, Author is Farrell, Nicholas; Kelland, Lloyd R.; Roberts, John D.; Van Beusichem, Marijo, the main research direction is trans platinum antitumor complex resistance structure.Safety of cis-Dichlorobis(pyridine)platinum(II).

The cytotoxicity of transplatinum complexes of structural formula trans-[PtCl2(L)L’)] {L = L’ = pyridine or thiazole, or L = quinoline (R’ = methyl; R” = Me, Ph or CH2phenyl) and L’ = R’R”SO] has been studied in murine L1210 and human tumor cell lines. The results confirm previous observations that use of a sterically hindered planar ligand greatly enhances cytotoxicity, in comparison to trans-[PtCl2(NH3)2], such that in some cases cytotoxicity equivalent to that of the clin. used agent cisplatin [cis-{PtCl2(NH3)2]] is obtained. Results from both the panel of human ovarian carcinoma cell lines and the National Cancer Institute screening panel confirm a different pattern of cytotoxicity, with respect to cisplatin. The new trans-platinum complexes are also non-cross-resistant with cisplatin in both murine and human (human ovarian carcinoma panel) tumor cell lines. Preliminary mechanistic studies using both cis- and trans-[PtCl2(pyridine)2] in L1210 cells have been carried out, to delineate the reasons for both the dramatically enhanced cytotoxicity and the lack of cross-resistance with the clin. used agents. Intracellular uptake is enhanced for pyridine relative to ammine (NH3) complexes. The pyridine complexes also inhibit DNA synthesis, implying a role for DNA binding in their mechanism of action. Binding of the pyridine complexes to calf thymus DNA is, however, significantly less than for the analogous ammine complexes. The presence of trans-pyridine ligands results in steric hindrance, which retards the rate of reaction of trans-[PtCl2(pyridine)2], relative to trans[PtCl2(NH3)2], with other important biomols. such as glutathione. The results point to a potential new class of platinum antitumor complexes acting by a new mechanism and with activity complementary to agents such as cisplatin.

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Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: cis-Dichlorobis(pyridine)platinum(II)(SMILESS: [Cl-][Pt+2]([N]1=CC=CC=C1)([Cl-])[N]2=CC=CC=C2,cas:15227-42-6) is researched.Related Products of 1452-77-3. The article 《The RP-HPLC measurement and QSPR analysis of log Po/w values of several Pt(II) complexes》 in relation to this compound, is published in Journal of Inorganic Biochemistry. Let’s take a look at the latest research on this compound (cas:15227-42-6).

The n-octanol/water partition coefficient, log Po/w, for a set of 24 Pt(II)-complexes was estimated by means of reversed-phase high performance liquid chromatog. (RP-HPLC) technique using a C18 (ODS, octadecyl silane) column as a stationary phase and water/methanol mixtures as mobile phases. Based on the known log P o/w of several Pt(II)-complexes, the authors set a method to correlate the partition coefficient of this kind of complexes with the corresponding retention parameters. The best result was obtained from extrapolation to 0% of the organic modifier (MeOH) of the aqueous eluant. A quant. structure-property relationship (QSPR) was constructed using mol. descriptors derived from d. functional theory (DFT) calculations, which was found to correlate and predict these values with good accuracy. The use of DFT calculations is required because group-additive methods fail due to lack of values for appropriate fragments for many Pt(II)-complexes.

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Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Related Products of 1452-77-3. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: Picolinamide, is researched, Molecular C6H6N2O, CAS is 1452-77-3, about Effect of nicotinamide on the flagellar detachment and regeneration of Euglena. Author is Okuwa-Hayashi, Hirotaka; Inui, Hiroshi; Inagaki, Junko; Nakazawa, Masami; Ebara, Shuhei; Enomoto, Toshiki; Sakamoto, Tatsuji; Nakano, Yoshihisa.

Euglena is capable of growth under various variety of nutritional and environmental conditions. Euglena is possible to grow under diverse culture conditions with and without light illumination, namely under both heterotrophic and photoautotrophic conditions. Euglena can synthesize most of vitamins and biofactors except for the exception, such as vitamin B1 and B12. In the present study, the effects of nicotinamide and its analogs on the flagellar detachment of Euglena were investigated using nicotinamide and the 12 kinds of structural analogs (nicotinic acid, pyrazine, pyrazine-2-carboxylic acid, 2-picolinamide, methylnicotinate, N-methylnicotinamide, 3-methylpyridine, pyridine-3-sulfate, pyridoxine, pyridoxal, pyridoxamine, isonicotinic acid hydrazide), NAD+, and NADP+. Among these compounds, nicotinamide, nicotinic acid, pyrazine-2-carboxylic acid, methylnicotinate, 2-picolinamide, and N-methylnicotinamide caused of the flagellar detachment and then cell division stopped. It was also found that nicotinamide added to Euglena cell was dilute with water and culture medium, cell division occurred and then flagella were regenerated after 24h, resulting in onset euglenoid exercise. The electrophoresis of the detached flagellar proteins reveled that the protein resembled tublin (55 kDa) and paraflagella rod 2 (69 KDa).

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Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Application In Synthesis of cis-Dichlorobis(pyridine)platinum(II). Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: cis-Dichlorobis(pyridine)platinum(II), is researched, Molecular C10H10Cl2N2Pt, CAS is 15227-42-6, about Solid-phase thermal transformations of platinum(IV) aminate complexes. Author is Kukushkin, Yu. N.; Sedova, G. N.; Belyaev, A. N.; Konovalov, L. V..

The thermal behavior of onium chloroplatinates of the type (AH)2[PtCl6] (A = NH3, MeNH2, 0.5 en, piperidine, py, γ-picoline, NH2Ph, p-toluidine, quinoline, 0.5 2,2′-bipyridine) was studied by derivatog. and IR spectral anal. The heating of solid (AH)2[PtCl6] led to the formation of trans-PtL2Cl4 (L = py, γ-picoline) and cis-PtQ2Cl4 (Q = p-toluidine) and subsequently to the formation of cis-PtA2Cl2. When (AH)2[PtCl6] (A = piperidine) was heated (AH)2[PtCl4] was formed. These results were compared with those for the corresponding palladates.

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Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Ionic liquid catalysed aerobic oxidative amidation and thioamidation of benzylic amines under neat conditions》. Authors are Joshi, Abhisek; Kumar, Rahul; Semwal, Rashmi; Rawat, Deepa; Adimurthy, Subbarayappa.The article about the compound:Picolinamidecas:1452-77-3,SMILESS:O=C(N)C1=NC=CC=C1).Safety of Picolinamide. Through the article, more information about this compound (cas:1452-77-3) is conveyed.

Tetrabutylammonium hydroxide (TBAOH) was discovered as a highly efficient and green catalyst for aerobic oxidation of the α-methylene carbon of primary amines as well as benzylic groups RCH2NH2 (R = Ph, pyren-1-yl, thiophene-2-yl, etc.) into the corresponding amides RC(O)NH2 and ketones R1C(O)C6H5 [R1 = Ph, pyridin-2-yl, C6H5C(O)] and 9H-fluoren-9-one under neat conditions. Ionic liquid TBAOH catalyzed aerobic oxidation of benzyl amines to benzamides and with elemental sulfur was described; and the corresponding benzylbenzothioamides RC(S)NHCH2R were obtained under metal-free, oxidant-free and base-free conditions. Applicability at the gram scale for the synthesis of the desired amides/ketones is also demonstrated with the present protocol.

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Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Application In Synthesis of cis-Dichlorobis(pyridine)platinum(II). So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: cis-Dichlorobis(pyridine)platinum(II), is researched, Molecular C10H10Cl2N2Pt, CAS is 15227-42-6, about Electrochemical properties of MC60 (M=Pd, Pt) covered electrodes.

The formation of electroactive films containing [60]fullerene and Pd or Pt was observed for solutions with the C60 and different metal complexes, Pd(PhCN)2Cl2, [Pd(CH3CO2)2]3, Pd(CH3CO2)2, [Pt(μ-Cl)Cl(C2H4)]2, cis-PtCl2(py)2, trans-PtCl2(py)2, and PtI2(py)2. Characterization of the film compositions by IR spectroscopy, MS and XPS shows that the films contain solely C60 and metal, as well as cations of the supporting electrolyte of the growth solution, that get incorporated during the cathodic growth process. Scanning electron micrographs of the films show that these consist mainly of spheres of ∼100 nm diameter and that the film thickness can be controlled by the number of cycles used during the growth process. The films show conductivity in the potential range of growth and this conductivity is both electronic and ionic and have thus potential application in high-d. energy storage devices.

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Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: cis-Dichlorobis(pyridine)platinum(II), is researched, Molecular C10H10Cl2N2Pt, CAS is 15227-42-6, about Interactions of an antitumor platinum compound with deoxyribonucleic acid, histones, L-amino acids, poly(L-amino acids), nucleosides, and nucleotides, the main research direction is neoplasm inhibitor platinum compound; DNA platinum compound; amino acid platinum compound; protein platinum compound; nucleic acid component platinum compound.SDS of cas: 15227-42-6.

The antitumor agents cis-dichloro(dipyridine)platinum(II) [15227-42-6] and cis-dichlorodiammineplatinum(II) [15663-27-1] interacted not only with DNA but also with amino acids, histones, polyamino acids, nucleosides, and nucleotides. The platinum complexes apparently associated with electron-rich areas of the various components. Such interactions could significantly affect pool levels of these cell components, cellular metabolism, and the pharmacol. action of the platinum compounds

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Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Category: tetrahydroisoquinoline. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: cis-Dichlorobis(pyridine)platinum(II), is researched, Molecular C10H10Cl2N2Pt, CAS is 15227-42-6, about Crystal and molecular structures of cis- and trans-dichlorobis(pyridine)platinum(II). Author is Colamarino, Paolo; Orioli, Pier L..

The crystal and mol. structures of cis- and trans-dichlorobis(pyridine)platinum (I, II resp.) were determined from x-ray diffractometer data by heavy-atom techniques and refined by least squares to R 0.041 and 0.068 for 1000 and 1032 observed intensities for I and II, resp. Crystals of I are monoclinic, space group C2/c, with a 9.408, b 17.110, c 15.270 Å, β 98.53.degree., and Z = 8. Crystals of II are triclinic, space group P1̅, with a 7.695, b 7.091, c 5.542 Å, α 87.6, β 83.7, γ 79.3.degree., and Z = 1. Both complexes consist of discrete mols. with Pt in square planar coordination.

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Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem