Madacsi, Ramona; Kanizsai, Ivan; Feher, Liliana Z.; Gyuris, Mario; Ozsvari, Bela; Erdelyi, Andras; Wolfling, Janos; Puskas, Laszlo G. published the artcile< Aromatic Sulfonamides Containing a Condensed Piperidine Moiety as Potential Oxidative Stress-Inducing Anticancer Agents>, Computed Properties of 115955-90-3, the main research area is N arylsulfonamide derivative anticancer agent oxidative stress cancer cell.
A 30-membered piperidine ring-fused aromatic sulfonamide library was synthesized, including N-arylsulfonyl 1,2,3,4-tetrahydroquinolines, 1,2,3,4-tetrahydroisoquinolines and 2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indoles. The compounds induced oxidative stress and glutathione depletion in HT168 melanoma and K562 leukemia cells and in micromolar concentrations exerted cytotoxic effects. Among the tested sulfonamides, compounds 21, 22, 23, 35 and 41 exhibited 100% cytotoxic effects with low (< 10 μM) EC50 values on K562 cells. The cytotoxicity of lead compound 22 was investigated in 24 different cancer cell lines, and it was found to be active against leukemia, melanoma, glioblastoma, and liver, breast and lung cancer cells, as confirmed by classical biochem. and holog. microscopic analyses. Medicinal Chemistry (Sharjah, United Arab Emirates) published new progress about Antitumor agents. 115955-90-3 belongs to class tetrahydroisoquinoline, and the molecular formula is C9H12N2, Computed Properties of 115955-90-3.
Referemce:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem