Resende, Diana I. S. P.; Almeida, Joana R.; Pereira, Sandra; Campos, Alexandre; Lemos, Agostinho; Plowman, Jeffrey E.; Thomas, Ancy; Clerens, Stefan; Vasconcelos, Vitor; Pinto, Madalena; Correia-da-Silva, Marta; Sousa, Emilia published the artcile< From Natural Xanthones to Synthetic C-1 Aminated 3,4-Dioxygenated Xanthones as Optimized Antifouling Agents>, Recommanded Product: 1,2,3,4-Tetrahydroisoquinolin-5-amine, the main research area is aminated dioxygenated xanthone preparation antifouling antibacterial; anti-settlement; antifouling; eco-friendly alternatives; molecular targets; xanthones.
In this work, the antifouling activity of a series of 24 xanthones I [R1 = Me, CH2Br, 4-ClC6H4CH2NHCH2, etc.; R2 = H, Cl; R3 = OMe; R4 = OH, OMe; R5 = H, OMe], with chem. similarities to natural products, was exploited. Nine of the tested xanthones presented highly significant anti-settlement responsed against the settlement of mussel Mytilus galloprovincialis larvae and low toxicity to this macrofouling species. Addnl., xanthone I [R1 = piperidinylmethyl; R2 = H; R3 = OMe; R4 = OMe; R5 = H] exhibited a therapeutic ratio (LC50/EC50) >15, as required by the US Navy program attesting its suitability as natural antifouling agents. From the nine tested xanthones, none of the compounds were found to significantly inhibit the growth of the marine biofilm-forming bacterial strains tested. Insights on the antifouling mode of action suggested that these two compounds affected similar mol. targets and cellular processes in mussel larvae, including that related to mussel adhesion capacity. This work exposed for the first time the relevance of C-1 aminated xanthones with a 3,4-dioxygenated pattern of substitution as new non-toxic products to prevent marine biofouling.
Marine Drugs published new progress about Antibacterial agents. 115955-90-3 belongs to class tetrahydroisoquinoline, and the molecular formula is C9H12N2, Recommanded Product: 1,2,3,4-Tetrahydroisoquinolin-5-amine.
Referemce:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem