《[2+3] Annulative Coupling of Tetrahydroisoquinolines with Aryliodonio diazo compounds To Access 1,2,4-Triazolo[3,4-a]isoquinolines》 was written by Ansari, Monish Arbaz; Khan, Shahnawaz; Ray, Subhasish; Shukla, Gaurav; Singh, Maya Shankar. Application In Synthesis of 7-Fluoro-1,2,3,4-tetrahydroisoquinoline hydrochloride And the article was included in Organic Letters on August 19 ,2022. The article conveys some information:
Base promoted one-pot annulative coupling of 1,2,3,4-tetrahydroisoquinolines (THIQs) with hypervalent iodine(III) species aryliodonio diazo compounds I (R = COOEt, COOtBu, COOBn, menthyl) has been devised for the direct construction of 1,2,4-triazolo[3,4-a]isoquinoline derivatives II (R = COOEt, COOtBu, COOBn, menthyl; R1 = H, 7-Me, 9-F, etc.) at room temperature in open air for the first time. This approach involves [2+3] cascade annulation of nucleophilic THIQ with an electrophilic aryliodonio diazo compound via N-H and α-C1(sp3)-H difunctionalization of THIQ. In the experiment, the researchers used many compounds, for example, 7-Fluoro-1,2,3,4-tetrahydroisoquinoline hydrochloride(cas: 799274-06-9Application In Synthesis of 7-Fluoro-1,2,3,4-tetrahydroisoquinoline hydrochloride)
7-Fluoro-1,2,3,4-tetrahydroisoquinoline hydrochloride(cas: 799274-06-9) belongs to tetrahydroisoquinoline. Tetrahydroisoquinoline Reactions: As a secondary amine, tetrahydroisoquinoline has weakly basic properties and forms salts with strong acids.Application In Synthesis of 7-Fluoro-1,2,3,4-tetrahydroisoquinoline hydrochloride It can be dehydrogenated to give isoquinoline and hydrogenated to decahydroisoquinoline. Like other secondary amines, tetrahydroisoquinoline can be oxidized to the corresponding nitrone using hydrogen peroxide, catalyzed by selenium dioxide.
Referemce:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem