Duan, Xiaonan; Wang, Xuepeng; Chen, Xingkun; Zhang, Jisong published the artcile< Continuous and Selective Hydrogenation of Heterocyclic Nitroaromatics in a Micropacked Bed Reactor>, Quality Control of 115955-90-3, the main research area is nitroisoquinoline nickel silica palladium aluminumoxide catalyst continous flow hydrogentaion; aminoisoquinoline regioselective preparation.
A continuous flow system based on a micropacked bed reactor was developed for the selective hydrogenation of heterocyclic nitroaroms. and the reductions of 5-nitroisoquinoline to 5-aminoisoquinoline and 5-amino-1,2,3,4-tetrahydroisoquinoline are selected as the model reactions. With the optimal reaction conditions, maximal yields of 99.9% (5-aminoisoquinoline) and 99.3% (5-amino-1,2,3,4-tetrahydroisoquinoline) were obtained successfully. Moreover, this system exhibits remarkable performance for the selective hydrogenation of relevant heterocyclic nitroaroms. with all yields beyond the level of 97.5%. The continuous flow system enables efficient hydrogenation of heterocyclic nitroaroms. and remarkable selectivity of target products with shorter reaction time and safer operation compared with batch reactors.
Organic Process Research & Development published new progress about Hydrogenation catalysts, regioselective. 115955-90-3 belongs to class tetrahydroisoquinoline, and the molecular formula is C9H12N2, Quality Control of 115955-90-3.
Referemce:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem