Ondachi, Pauline W. published the artcilePotent and Selective Tetrahydroisoquinoline Kappa Opioid Receptor Antagonists of Lead Compound (3R)-7-Hydroxy-N-[(1S)-2-methyl-1-(piperidin-1-ylmethyl)propyl]-1,2,3,4-tetrahydroisoquinoline-3-carboxamide (PDTic), COA of Formula: C15H19NO5, the publication is Journal of Medicinal Chemistry (2018), 61(17), 7525-7545, database is CAplus and MEDLINE.
Past studies have shown that it was difficult to discover and develop potent and selective κ opioid receptor antagonists, particularly compounds having potential for clin. development. In this study, we present a structure-activity relation (SAR) study of a recently discovered new class of tetrahydroisoquinoline κ opioid receptor antagonists which led to (3R)-7-hydroxy-N-{(1S)-2-methyl-1-[(-4-methylpiperidine-1-yl)methyl]propyl}-1,2,3,4-tetrahydroisoquinoline-3-carboxamide I (4-Me-PDTic). Compound I had a Ke = 0.37 nM in a [35S]GTPγS binding assay and was 645- and >8100-fold selective for the κ relative to the μ and δ opioid receptors, resp. Calculated log BB and CNS (central nervous system) multiparameter optimization (MPO) and low mol. weight values all predict that 12 will penetrate the brain, and pharmacokinetic studies in rats show that I does indeed penetrate the brain.
Journal of Medicinal Chemistry published new progress about 142335-42-0. 142335-42-0 belongs to tetrahydroisoquinoline, auxiliary class Tetrahydroisoquinoline,Chiral,Carboxylic acid,Amide,Alcohol, name is (S)-2-(tert-Butoxycarbonyl)-7-hydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid, and the molecular formula is C15H19NO5, COA of Formula: C15H19NO5.
Referemce:
https://en.wikipedia.org/wiki/Tetrahydroisoquinoline,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem