Hydroxyguanidines. New class of antihypertensive agents was written by Bailey, Denis M.;DeGrazia, C. George;Lape, Harlan E.;Frering, Richard;Fort, Dorothy;Skulan, Thomas. And the article was included in Journal of Medicinal Chemistry in 1973.HPLC of Formula: 207451-81-8 This article mentions the following:
3,4-Dihydro-1-methyl-2(1H)-isoquinolinecarboxamidoxime (I) [26193-33-9] and (1R,3S)-3,4-dihydro-1,3-dimethyl-2(1H)-isoquinolinecarboxamidoxime (II) [39219-29-9] had strong antihypertensive activity in exptl. hypertensive rats and dogs (oral ED 0.3-1.25 mg/kg/day chronically in dogs for both compounds). Cross-circulation experiments, in which the head vasculature of a dog was isolated from the systemic circulation and supplied with blood from a donor animal treated with I or II, showed that they penetrated the blood-brain barrier and produced centrally-induced systemic blood pressure decreases, owing to their reduced basicity compared to the corresponding guanidines. I was prepared by reaction of 1,2,3,4-tetrahydro-1-methylisoquinoline [4965-09-7] with cyanogen bromide [506-68-3], and reaction of the resulting nitrile with NH2OH. In the experiment, the researchers used many compounds, for example, 7-Methyl-1,2,3,4-tetrahydroisoquinoline (cas: 207451-81-8HPLC of Formula: 207451-81-8).
7-Methyl-1,2,3,4-tetrahydroisoquinoline (cas: 207451-81-8) belongs to tetrahydroisoquinoline derivatives. Tetrahydroisoquinoline motif is often present in natural products with a broad range of biological and pharmacological activities. Among them, 1-substituted tetrahydroisoquinolines are privileged scaffolds in drugs and pharmaceuticals. An efficient CuCl2-catalyzed coupling of nonfunctionalized tetrahydroisoquinolines with organozinc reagents under aerobic conditions proceeds in high yields under mild reaction conditions and is broadly applicable to a wide range of substrates. The reaction involves an iminium ion intermediate that is formed via a SET process.HPLC of Formula: 207451-81-8
Referemce:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem