Electrosynthesis of polycyclic quinazolinones and rutaecarpine from isatoic anhydrides and cyclic amines was written by Chen, Xingyu;Zhang, Xing;Lu, Sixian;Sun, Peng. And the article was included in RSC Advances in 2020.Quality Control of 7-Methyl-1,2,3,4-tetrahydroisoquinoline This article mentions the following:
A direct decarboxylative cyclization between readily available isatoic anhydrides I [R = H, 8-Me, 5,7-(Cl)2, etc.] and cyclic amines II (R1 = H, Me, OMe, F, NO2; R2 = H, OMe; n = 0, 1) was established to construct polycyclic fused quinazolinones III [R3 = H, 11-OMe, 9,11-(Cl)2, etc.] employing electrochem. methods. This procedure was performed in an undivided cell without the use of a transition-metal-catalyst and external oxidant. A broad scope of polycyclic fused quinazolinones III was obtained in moderate to good yields. Addnl., rutaecarpine was also prepared through this method in one step in good yield. In the experiment, the researchers used many compounds, for example, 7-Methyl-1,2,3,4-tetrahydroisoquinoline (cas: 207451-81-8Quality Control of 7-Methyl-1,2,3,4-tetrahydroisoquinoline).
7-Methyl-1,2,3,4-tetrahydroisoquinoline (cas: 207451-81-8) belongs to tetrahydroisoquinoline derivatives. The tetrahydroisoquinoline skeleton is encountered in a number of bioactive compounds and drugs. Arene/Ru/TsDPEN complexes bearing a heterocyclic group catalyze the asymmetric transfer hydrogenation (ATH) of 1-aryl dihydroisoquinolines (DHIQs) to provide tetrahydroisoquinolines of high enantiomeric excess.Quality Control of 7-Methyl-1,2,3,4-tetrahydroisoquinoline
Referemce:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem