CuII/TEMPO-Catalyzed Enantioselective C(sp3)-H Alkynylation of Tertiary Cyclic Amines through Shono-Type Oxidation was written by Gao, Pei-Sen;Weng, Xin-Jun;Wang, Zhen-Hua;Zheng, Chao;Sun, Bing;Chen, Zhi-Hao;You, Shu-Li;Mei, Tian-Sheng. And the article was included in Angewandte Chemie, International Edition in 2020.Application of 207451-81-8 This article mentions the following:
A novel strategy for asym. Shono-type oxidative cross-coupling has been developed by merging copper catalysis and electrochem., affording C1-alkynylated tetrahydroisoquinolines with good to excellent enantioselectivity. The use of TEMPO as a co-catalytic redox mediator is crucial not only for oxidizing a tetrahydroisoquinoline to an iminium ion species but also for decreasing the oxidation potential of the reaction. A novel bisoxazoline ligand is also reported. In the experiment, the researchers used many compounds, for example, 7-Methyl-1,2,3,4-tetrahydroisoquinoline (cas: 207451-81-8Application of 207451-81-8).
7-Methyl-1,2,3,4-tetrahydroisoquinoline (cas: 207451-81-8) belongs to tetrahydroisoquinoline derivatives. There has been increasing research interest and speculation since 1968 in the potential formation of tetrahydroisoquinoline (TIQ) alkaloids in mammalian cells via such interactions, and in the role such TIQs may have in alcohol dependence. Like other secondary amines, tetrahydroisoquinoline can be oxidized to the corresponding nitrone using hydrogen peroxide, catalyzed by selenium dioxide.Application of 207451-81-8
Referemce:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem