Electrochemical Approach for Direct C-H Phosphonylation of Unprotected Secondary Amine was written by Huang, Min;Dai, Jie;Cheng, Xu;Ding, Mengning. And the article was included in Organic Letters in 2019.Category: tetrahydroisoquinoline This article mentions the following:
Direct α-phosphonylation of an unprotected secondary amine in a single step is of practical importance to aminophosphates. However, this protocol is limited due to the high redox barrier of unprotected amine. The authors report C-H phosphonylation of an unprotected secondary amine via an electrochem. approach in the presence of catalytic carboxylate salt. This metal-free and exogenous oxidant-free method furnishes diverse target mols. with satisfactory yield under mild reaction conditions. Successful application of the protocol in a gram-scale experiment demonstrates the potential utility for further functionalization. In the experiment, the researchers used many compounds, for example, 7-Methyl-1,2,3,4-tetrahydroisoquinoline (cas: 207451-81-8Category: tetrahydroisoquinoline).
7-Methyl-1,2,3,4-tetrahydroisoquinoline (cas: 207451-81-8) belongs to tetrahydroisoquinoline derivatives. The tetrahydroisoquinoline skeleton is encountered in a number of bioactive compounds and drugs. An oxidative C1 arylation of tetrahydroisoquinolines with aryl Grignard reagents is mediated by diethyl azodicarboxylate (DEAD). This C-H activation under metal-free conditions delivers target compounds, including some naturally occurring alkaloids, in good yields.Category: tetrahydroisoquinoline
Referemce:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem