Intramolecular Reductive Cyclization of o-Nitroarenes via Biradical Recombination was written by Lu, Cong;Su, Zhishan;Jing, Dong;Jin, Songyang;Xie, Lijuan;Li, Liangrui;Zheng, Ke. And the article was included in Organic Letters in 2019.Product Details of 207451-81-8 This article mentions the following:
A visible-light-induced/thiourea-mediated intramol. cyclization of o-nitroarenes under mild conditions is realized for the first time, which provides an efficient and environmentally friendly way to access pharmaceutical relevant quinazolinone derivs I (R1 = H, 9-Me, 9-F, 10-MeO, etc.; R2 = H, 4-F, 4-Br, 3-F, 2-Me, etc.; R3 = H, (S)-5-Me, etc.). The reaction can be easily extended to gram level by using a continuous-flow setup with high efficiency. Mechanistic investigation including control experiments, transient fluorescence, UV-vis spectra, and DFT calculations suggests that the formation of active biradical intermediates via intramol. single electron transfer (SET) is key stage in the catalytic cycle. In the experiment, the researchers used many compounds, for example, 7-Methyl-1,2,3,4-tetrahydroisoquinoline (cas: 207451-81-8Product Details of 207451-81-8).
7-Methyl-1,2,3,4-tetrahydroisoquinoline (cas: 207451-81-8) belongs to tetrahydroisoquinoline derivatives. Tetrahydroisoquinoline motif is often present in natural products with a broad range of biological and pharmacological activities. Because of the high biological relevance of compounds possessing the 1,2,3,4-tetrahydroisoquinoline framework, a large number of synthetic approaches towards the creation of an isoquinoline or 1,2,3,4-tetrahydroisoquinoline core are presently known. However, synthetic routes to tetrahydroisoquinoline derivatives containing fluorine atom(s) in their structure are not particularly abundant.Product Details of 207451-81-8
Referemce:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem