Directed (R)- or (S)-selective dynamic kinetic enzymatic hydrolysis of 1,2,3,4-tetrahydroisoquinoline-1-carboxylic esters was written by Paal, Tihamer A.;Liljeblad, Arto;Kanerva, Liisa T.;Forro, Eniko;Fulop, Ferenc. And the article was included in European Journal of Organic Chemistry in 2008.Computed Properties of C10H11NO2 This article mentions the following:
The first synthesis of both enantiomers of 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid (I) was accomplished through dynamic kinetic resolution in procedures based on CAL-B- or subtilisin Carlsberg-catalyzed enantioselective hydrolysis of the corresponding Et esters in aqueous NH4OAc buffer at pH 8.5. The products were obtained with high enantiopurity (92-93% ee) in good yields (85-92%). (R)-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid (II) was obtained with high enantiopurity (98% ee) and in good yield (85%) in a CAL-B-catalyzed process, under similar conditions. In the experiment, the researchers used many compounds, for example, (S)-1,2,3,4-Tetrahydroisoquinoline-1-carboxylic acid (cas: 151004-92-1Computed Properties of C10H11NO2).
(S)-1,2,3,4-Tetrahydroisoquinoline-1-carboxylic acid (cas: 151004-92-1) belongs to tetrahydroisoquinoline derivatives. Tetrahydroisoquinoline motif is often present in natural products with a broad range of biological and pharmacological activities. Among them, 1-substituted tetrahydroisoquinolines are privileged scaffolds in drugs and pharmaceuticals. Tetrahydroisoquinoline derivatives may be formed in the body as metabolites of some drugs, and this was once thought to be involved in the development of alcoholism.This is no longer generally accepted by the scientific community.Computed Properties of C10H11NO2
Referemce:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem