Metal- and Additive-Free Aerobic Dehydrogenation of N-Heterocycles and Hydrocarbons by N-Doped Carbon was written by Shang, Sensen;Li, Yingguang;Lv, Ying;Dai, Wen. And the article was included in Asian Journal of Organic Chemistry in 2022.HPLC of Formula: 207451-81-8 This article mentions the following:
N-doped hierarchical pore carbons (N-HPCs) derived from readily available biomass (flour) efficiently catalyzed aerobic dehydrogenation of N-heterocycles without any additives under mild conditions was describeed, owing to N dopant and high surface area indicated by characterization anal. A wide range of N-heteroarenes including quinolines, quinolinol, dihydroisoquinolines, isoquinolines, indoles, quinoxaline and acridine were obtained in good to excellent yields (36 examples, up to 99% yield). Mechanistic studies revealed a strikingly different non-free radical process from metal catalysts, for which an apparent activation energy of 66.4 kJ mol-1 was found. Moreover, the N-doped carbon exhibited robust stability and yielded 74.5% quinoline at the sixth reaction. This work provides a promising example for metal-free catalysis. In the experiment, the researchers used many compounds, for example, 7-Methyl-1,2,3,4-tetrahydroisoquinoline (cas: 207451-81-8HPLC of Formula: 207451-81-8).
7-Methyl-1,2,3,4-tetrahydroisoquinoline (cas: 207451-81-8) belongs to tetrahydroisoquinoline derivatives. Tetrahydroisoquinoline motif is often present in natural products with a broad range of biological and pharmacological activities. In particular, 1-benzyl1,2,3,4-tetrahydroisoquinolines are dopamine receptor antagonists. Like other secondary amines, tetrahydroisoquinoline can be oxidized to the corresponding nitrone using hydrogen peroxide, catalyzed by selenium dioxide.HPLC of Formula: 207451-81-8
Referemce:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem