Iron-catalyzed α-C-H functionalization of π-bonds: cross-dehydrogenative coupling and mechanistic insights was written by Wang, Yidong;Zhu, Jin;Guo, Rui;Lindberg, Haley;Wang, Yi-Ming. And the article was included in Chemical Science in 2020.Application In Synthesis of 7-Methyl-1,2,3,4-tetrahydroisoquinoline This article mentions the following:
In this article, the use of dicarbonyl cyclopentadienyliron(II) complexes for the generation of propargylic anion equivalent toward the direct electrophilic functionalization of propargylic C-H bonds under mild, catalytic conditions were reported. This technol. was applied to the direct conversion of C-H bonds to C-C bonds for the synthesis of several functionalized scaffolds through a one-pot cross dehydrogenative coupling reaction with tetrahydroisoquinoline and related privileged heterocyclic scaffolds. A series of NMR studies and deuterium-labeling experiments indicated that the deprotonation of the propargylic C-H bond was the rate-determining step when a Cp*Fe(CO)2-based catalyst system was employed. In the experiment, the researchers used many compounds, for example, 7-Methyl-1,2,3,4-tetrahydroisoquinoline (cas: 207451-81-8Application In Synthesis of 7-Methyl-1,2,3,4-tetrahydroisoquinoline).
7-Methyl-1,2,3,4-tetrahydroisoquinoline (cas: 207451-81-8) belongs to tetrahydroisoquinoline derivatives. Tetrahydroisoquinoline can be dehydrogenated to give isoquinoline and hydrogenated to decahydroisoquinoline. Like other secondary amines, tetrahydroisoquinoline can be oxidized to the corresponding nitrone using hydrogen peroxide, catalyzed by selenium dioxide.Application In Synthesis of 7-Methyl-1,2,3,4-tetrahydroisoquinoline
Referemce:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem