Synthesis and SAR of tetrahydroisoquinolines as Rev-erb伪 agonists was written by Noel, Romain;Song, Xinyi;Shin, Youseung;Banerjee, Subhashis;Kojetin, Douglas;Lin, Li;Ruiz, Claudia H.;Cameron, Michael D.;Burris, Thomas P.;Kamenecka, Theodore M.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2012.Formula: C12H15NO2 This article mentions the following:
The design and synthesis of a novel series of Rev-erb伪 agonists is described. The development and optimization of the tetrahydroisoquinoline series was carried out from an earlier acyclic series of Rev-erb伪 agonists. Through the optimization of the scaffold I, several potent compounds with good in vivo profiles were discovered. In the experiment, the researchers used many compounds, for example, Ethyl 1,2,3,4-tetrahydroisoquinoline-3-carboxylate (cas: 41234-43-9Formula: C12H15NO2).
Ethyl 1,2,3,4-tetrahydroisoquinoline-3-carboxylate (cas: 41234-43-9) belongs to tetrahydroisoquinoline derivatives. Tetrahydroisoquinoline motif is often present in natural products with a broad range of biological and pharmacological activities. In particular, 1-benzyl1,2,3,4-tetrahydroisoquinolines are dopamine receptor antagonists. The dopamine-derived tetrahydroisoquinolines (TIQ) synthesized endogeneously from aldehydes and catecholamines have shown to modulate neurotransmission, central metabolism and motor activity.Formula: C12H15NO2
Referemce:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem