Santangelo Freel, Rose M. et al. published their research in Journal of Medicinal Chemistry in 2014 | CAS: 2328-12-3

Synthesis and Structure Activity Relationship of Tetrahydroisoquinoline-Based Potentiators of GluN2C and GluN2D Containing N-Methyl-D-aspartate Receptors [Erratum to document cited in CA159:150256] was written by Santangelo Freel, Rose M.;Ogden, Kevin K.;Strong, Katie L.;Khatri, Alpa;Chepiga, Kathryn M.;Jensen, Henrik S.;Traynelis, Stephen F.;Liotta, Dennis C.. And the article was included in Journal of Medicinal Chemistry in 2014.Category: tetrahydroisoquinoline This article mentions the following:

The description of the model shown in Figure 3 predicts the wrong stereochem. of the amine resulting from the stereoselective reduction of the imine; the corrected stereochem. is given, along with a discussion of the effects. In the experiment, the researchers used many compounds, for example, 6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride (cas: 2328-12-3Category: tetrahydroisoquinoline).

6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride (cas: 2328-12-3) belongs to tetrahydroisoquinoline derivatives. Tetrahydroisoquinoline motif is often present in natural products with a broad range of biological and pharmacological activities. An intramolecular Friedel-Crafts cyclization of an in situ generated tosylate intermediate enables an efficient construction of 3-substituted 1,2,3,4-tetrahydroisoquinolines from N,N-dibenzyl-伪-aminols.Category: tetrahydroisoquinoline

Referemce:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem