Biodegradable neuromuscular blocking agents. Part 3. Bisquaternary esters was written by Stenlake, John B.;Waigh, Roger D.;Urwin, John;Dewar, George H.;Hughes, Roy;Chapple, Dennis J.. And the article was included in European Journal of Medicinal Chemistry in 1981.Electric Literature of C11H16ClNO2 This article mentions the following:
Alkylenebis[tetrahydroisoquinolinium] derivatives, e.g. I (n = 4, 6, 8, 10) and II [R = H, 2-cyclopenten-1-ylmethyl, 3,4-(MeO)2C6H3CH2] were prepared Thus, 3,4-(MeO)2C6H3CH2CH2NHCO(CH2)4CONHCH2CH2C6H3(OMe)2-3,4 was cyclized to a bisdihydroisoquinoline, which was reduced followed by treatment with H2C:CHCO2Me and MeI to give I (n = 4). The compounds were tested as potential neuromuscular blocking agents in cats. Variations in duration of action, potency and vagal block are reported and related to structure. In the experiment, the researchers used many compounds, for example, 6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride (cas: 2328-12-3Electric Literature of C11H16ClNO2).
6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride (cas: 2328-12-3) belongs to tetrahydroisoquinoline derivatives. The tetrahydroisoquinoline skeleton is present in a number of drugs, such as tubocurarine, one of the quaternary ammonium muscle relaxants. Arene/Ru/TsDPEN complexes bearing a heterocyclic group catalyze the asymmetric transfer hydrogenation (ATH) of 1-aryl dihydroisoquinolines (DHIQs) to provide tetrahydroisoquinolines of high enantiomeric excess.Electric Literature of C11H16ClNO2
Referemce:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem