Month: February 2023

Chachoyan, A. A. et al. published their research in Biologicheskii Zhurnal Armenii in 1972 | CAS: 2328-12-3

6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride (cas: 2328-12-3) belongs to tetrahydroisoquinoline derivatives. Tetrahydroisoquinoline, as a secondary amine, tetrahydroisoquinoline has weakly basic properties and forms salts with strong acids. An oxidative C1 arylation of tetrahydroisoquinolines with aryl Grignard reagents is mediated by diethyl azodicarboxylate (DEAD). This C-H activation under metal-free conditions delivers target compounds, including some naturally occurring alkaloids, in good yields.COA of Formula: C11H16ClNO2

Antineoplastic activity of some tetrahydroisoquinoline derivatives was written by Chachoyan, A. A.;Garibdzhanyan, B. T.;Markaryan, E. Z.. And the article was included in Biologicheskii Zhurnal Armenii in 1972.COA of Formula: C11H16ClNO2 This article mentions the following:

6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline-HCl (I) [2328-12-3] and similar compounds inhibited by 60-79% the growth of sarcoma 45 in rats. The compound had little or no activity against Walker carcinosarcoma or Ehrlich ascites carcinoma. In the experiment, the researchers used many compounds, for example, 6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride (cas: 2328-12-3COA of Formula: C11H16ClNO2).

6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride (cas: 2328-12-3) belongs to tetrahydroisoquinoline derivatives. Tetrahydroisoquinoline, as a secondary amine, tetrahydroisoquinoline has weakly basic properties and forms salts with strong acids. An oxidative C1 arylation of tetrahydroisoquinolines with aryl Grignard reagents is mediated by diethyl azodicarboxylate (DEAD). This C-H activation under metal-free conditions delivers target compounds, including some naturally occurring alkaloids, in good yields.COA of Formula: C11H16ClNO2

Referemce:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Stanforth, Stephen P. et al. published their research in Tetrahedron in 2000 | CAS: 2328-12-3

6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride (cas: 2328-12-3) belongs to tetrahydroisoquinoline derivatives. Tetrahydroisoquinoline, as a secondary amine, tetrahydroisoquinoline has weakly basic properties and forms salts with strong acids. Like other secondary amines, tetrahydroisoquinoline can be oxidized to the corresponding nitrone using hydrogen peroxide, catalyzed by selenium dioxide.HPLC of Formula: 2328-12-3

Ring-opening reactions of N-aryl-1,2,3,4-tetrahydroisoquinolines: synthesis of novel isoquino[2,1-a][3,1]benzoxazine derivatives was written by Stanforth, Stephen P.. And the article was included in Tetrahedron in 2000.HPLC of Formula: 2328-12-3 This article mentions the following:

The aldehydes 2,4-AcOCH2(O2N)C6H3NHCH2CH2C6H2R2CHO-4,5,2 [I, R = H, OMe] were prepared by treatment of the corresponding 1,2,3,4-tetrahydroisoquinolines with N-bromosuccinimide (NBS). Basic hydrolysis of I gave the 4bH,6H-isoquino[2,1-a][3,1]benzoxazine derivatives An ethoxy derivative was obtained directly from the reaction of the tetrahydroisoquinolines with NBS. In the experiment, the researchers used many compounds, for example, 6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride (cas: 2328-12-3HPLC of Formula: 2328-12-3).

6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride (cas: 2328-12-3) belongs to tetrahydroisoquinoline derivatives. Tetrahydroisoquinoline, as a secondary amine, tetrahydroisoquinoline has weakly basic properties and forms salts with strong acids. Like other secondary amines, tetrahydroisoquinoline can be oxidized to the corresponding nitrone using hydrogen peroxide, catalyzed by selenium dioxide.HPLC of Formula: 2328-12-3

Referemce:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem