Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments. Application In Synthesis of 1,2,3,4-Tetrahydroisoquinoline-7-carbonitrile. Introducing a new discovery about 149355-52-2, Name is 1,2,3,4-Tetrahydroisoquinoline-7-carbonitrile
Electrochemical Approach for Direct C-H Phosphonylation of Unprotected Secondary Amine
Direct alpha-phosphonylation of an unprotected secondary amine in a single step is of practical importance to amino phophophates. However, this protocol is limited due to the high redox barrier of unprotected amine. In this paper, we report C-H phosphonylation of an unprotected secondary amine via an electrochemical approach in the presence of catalytic carboxylate salt. This metal-free and exogenous oxidant-free method furnishes diverse target molecules with satisfactory yield under mild reaction conditions. Successful application of the protocol in a gram-scale experiment demonstrates the potential utility for further functionalization.
Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.Application In Synthesis of 1,2,3,4-Tetrahydroisoquinoline-7-carbonitrile, you can also check out more blogs about149355-52-2
Reference£º
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem