In heterogeneous catalysis, the catalyst is in a different phase from the reactants. SDS of cas: 170097-67-3, At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 170097-67-3, name is 2-(tert-Butoxycarbonyl)-1,2,3,4-tetrahydroisoquinoline-6-carboxylic acid. In an article£¬Which mentioned a new discovery about 170097-67-3
Discovery of brain penetrant, soluble, pyrazole amide EP1 receptor antagonists
We describe the discovery of a series of pyrazole amide EP1 receptor antagonists with good aqueous solubility and CNS penetration. In order to achieve solubility we investigated the incorporation of a basic group in the region of the molecule previously occupied by a carboxylic acid, which was known to be a key element of the pharmacophore. This study led to the identification of compounds such as 4h, 4j and 10b which demonstrated brain-to-blood ratios of 0.8:1-2.0:1 in addition to good solubility and metabolic stability.
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Reference£º
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem