The important role of 7-Nitro-1,2,3,4-tetrahydroisoquinoline

One of the oldest and most widely used commercial enzyme inhibitors is aspirin, Product Details of 42923-79-5, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 42923-79-5

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, Product Details of 42923-79-5, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 42923-79-5, Name is 7-Nitro-1,2,3,4-tetrahydroisoquinoline, molecular formula is C9H10N2O2

DEAD-Promoted Oxidative Ugi-Type Reaction Including an Unprecedented Ugi Amidation Assisted by Dicarboxylic Acids

A mild and metal-free DEAD-promoted (DEAD = diethyl azodicarboxylate) oxidative Ugi-type reaction of tertiary amines has been demonstrated. The reaction gives easy access to alpha-amino amides and imides with diverse functional groups in good isolated yields. This Ugi-type approach achieves an unprecedented synthesis of alpha-amino amide analogues with the assistance of dicarboxylic acids, and not water, for the introduction of the carbonyl oxygen atom of the amide moiety. Mechanistic studies indicated that the dicarboxylic acids may readily undergo an intramolecular annulation, instead of the Mumm rearrangement, to give the desired amide with one molecule of anhydride released.

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Reference£º
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem