Electric Literature of 799274-08-1, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 799274-08-1, Name is 6-Fluoro-1,2,3,4-tetrahydroisoquinoline hydrochloride, molecular formula is C9H11ClFN. In a Article£¬once mentioned of 799274-08-1
Synthesis of 3-Benzazepines by Metal-Free Oxidative C?H Bond Functionalization?Ring Expansion Tandem Reaction
A metal-free synthesis of biologically important benzazepines is achieved through a single synthetic operation involving an oxidative C?H bond functionalization and ring expansion with diazomethanes as key reagent. This represents a new, strong methodology for the straightforward construction of the seven-ring N-heterocyclic structures under mild conditions using a 2,2,6,6-tetramethylpiperidine 1-oxyl (TEMPO) oxoammonium salt as oxidant. Moderate to good yields are achieved from simple, readily available tetrahydroisoquinolines, and this methodology has been further successfully applied for the synthesis of the 3-benzazepine drug Lorcaserin. A possible mechanistic pathway for the ring expansion step, comprising the extrusion of nitrogen in a concerted asynchronic process, is proposed based on both mechanistic proof and density function theory (DFT) calculations. (Figure presented.).
Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Electric Literature of 799274-08-1. In my other articles, you can also check out more blogs about 799274-08-1
Reference£º
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem