In heterogeneous catalysis, the catalyst is in a different phase from the reactants. Formula: C15H15N, At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 22990-19-8, name is 1-Phenyl-1,2,3,4-tetrahydroisoquinoline. In an article£¬Which mentioned a new discovery about 22990-19-8
Palladium-Catalyzed C(sp3)-H Arylation of N-Boc Benzylalkylamines via a Deprotonative Cross-Coupling Process
Diarylmethylamines are key intermediates and products in the pharmaceutical industry. Herein we disclose a novel method toward the synthesis of these important compounds via C-H functionalization. Presented is a reversible deprotonation of N-Boc benzylalkylamines at the benzylic C-H with in situ arylation by a NiXantPhos-based palladium catalyst (50-93 % yield, 29 examples). The method is also successful with N-Boc-tetrahydroisoquinolines. The advantages of this method are it avoids strong bases, low temperatures, and the need to transmetallate to main group metals for the coupling. Skipping steps! Diarylmethylamines are key intermediates and products in the pharmaceutical industry. A novel method toward the synthesis of these important compounds via C-H functionalization is reported. A reversible deprotonation of N-Boc benzylalkylamines at the benzylic C-H is coupled with in situ arylation with a (NiXantPhos)Pd-based catalyst (50-93 % yield, 29 examples). The advantages of this method are that it avoids strong bases, low temperatures, and the need to transmetallate to main group metals for the coupling.
I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 22990-19-8, help many people in the next few years.Formula: C15H15N
Reference£º
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem