With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.82771-60-6,7-Chloro-1,2,3,4-tetrahydroisoquinoline,as a common compound, the synthetic route is as follows.,82771-60-6
General procedure: To ice cold solutions of substituted-1,2,3,4-tetrahydroisoquinolines (1) (1.5 mmol) in a mixture of 2 mL of acetic acid and 2.2 mL of H2O, aqueous solutions of sodium nitrite (NaNO2, 4.5 mmol) in 1.5 mL of H2O were added drop by drop over 2 min at 0 C. in an ice-water bath. The reaction mixtures were stirred for 3 h. (0165) Thin Layer Chromatography (TLC) indicated that the reactions were complete. The reaction mixtures were extracted with CH2Cl2 and the organic layers were washed thrice with brine and dried over sodium sulfate. The solvents were evaporated in vacuo to obtain the crude products. Some products were purified at this stage. For example, 7-Chloro-2-nitroso-1,2,3,4-tetrahdyroisoquinoline was column chromatographed (3:1 Hexane:Ethylacetate, gradient elution) using combiflash column chromatography. The desired compound was obtained in moderate yields (62%). RRN 777-Chloro-2-nitroso-1, 2, 3, 4-tetrahydroisoquinoline (0166) 1HNMR (CDCl3): delta 3.02-3.13 (m, 2H, -CH2), 4.49-4.53 (m, 2H, -CH2), 4.76 (s, 2H, -CH2), 7.13-7.25 (m, 3H, C1?-C4?-H).
As the paragraph descriping shows that 82771-60-6 is playing an increasingly important role.
Reference£º
Patent; Florida A&M University; Redda, Kinfe Ken; Eyunni, Suresh Kumar V. K.; (40 pag.)US2019/100495; (2019); A1;,
Tetrahydroisoquinoline – Wikipedia
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem