22990-19-8, 1-Phenyl-1,2,3,4-tetrahydroisoquinoline is a tetrahydroisoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a solution of a compound 3-benzylaza-bicyclo[3.1.0]hexan-6-amine (0.2 g, 0.001 mol) [prepared following the procedure as described in Synlett, 1097-1102 (1996)] in acetonitrile (10 ml), was added p-nitrophenyl chloroformate (0.216 g, 0.001 mol) and triethylamine (0.214 g, 0.00212 mol). The resulting reaction mixture was stirred at room temperature for 3 hours followed by the addition of 1 -phenyl- 1,2,3, 4- tetrahydroisoquinoline (0.2 Ig, 0.001 mol). The reaction mixture was refluxed for 12 hours followed by cooling it to room temperature. The contents of the reaction mixture were poured into water and extracted with ethyl acetate. The organic layer was dried over anhydrous sodium sulphate and concentrated under reduced pressure. The residue thus obtained was purified by column chromatography using ethyl acetate and hexane solvent mixture to furnish the title compound. Yield: 0.11 g.1H NMR (CDCl3): 7.37-7.06 (m, 14H), 6.30 (s, IH), 4.84 (bs, IH), 3.58 (s, 2H), 3.56-3.49 (m, 2H), 3.11-2.74 (m, 7H), 1.26 (s, 2H); IR (DCM): 1622 cm”1
22990-19-8, 22990-19-8 1-Phenyl-1,2,3,4-tetrahydroisoquinoline 100137, atetrahydroisoquinoline compound, is more and more widely used in various fields.
Reference£º
Patent; RANBAXY LABORATORIES LIMITED; WO2006/35280; (2006); A1;,
Tetrahydroisoquinoline – Wikipedia
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem