With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.57060-88-5,Methyl 1,2,3,4-tetrahydroisoquinoline-3-carboxylate hydrochloride,as a common compound, the synthetic route is as follows.,57060-88-5
Example 38; 2-[2-(3-Carboxy-6,8-dichloronaphthalen-1-yloxy)-acetyl]-1, 2,3,4- tetrahydroisoquinoline-3-carboxylic acid[00122] The title compound is prepared by the following reaction sequence: a) a mixture of 1 ,2,3,4-tetrahydroisoquinoline-3-carboxylic acid methyl ester hydrochloride (10bc) (108 mg, 0.47 mmol), 5,7-dichloro-4- chlorocarbonylmethoxynaphthalene-2-carboxylic acid methyl ester (9a) (150 mg, 0.43 mmol) and TEA (0.21 mL, 5.51 mmol) in CH2CI2 (4 ml_) is stirred at rt for 3 days. After evaporation under reduced pressure, the residue is purified by flash chromatography to give 2-[2-(6,8-dichloro-3-methoxycarbonylnaphthalen-1 -yloxy)-acetyl]-1 ,2,3,4- tetrahydroisoquinoline-3-carboxylic acid methyl ester (13bi) (207 mg, 95%).
The synthetic route of 57060-88-5 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; MERZ PHARMA GMBH &; CO. KGAA; HENRICH, Markus; BAUER, Angela; NAGEL, Jens; KAUSS, Valerjans; TRIFANOVA, Dina; GRUNSTEINE, Ginta; ROZHKOVS, Jevgenijs; WO2010/139481; (2010); A1;,
Tetrahydroisoquinoline – Wikipedia
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem