Awesome and Easy Science Experiments about 6-Methoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride

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Acylhydrazone as a novel “off-On-Off” fluorescence probe for the sequential detection of Al3+ and F-

A new acylhydrazone fluorescence probe, SPBH, was synthesized from salicylaldehyde and 4-(pyridin-4-yl)benzohydrazide (PBH). SPBH exhibited high selectivity and a sensitive fluorescence response towards Al3+, even in the presence of other competing metal ions in DMF/H2O (1:1, v/v) medium. And, the chemosensor can even detect Al3+ in the intracellular region of human non-small cell lung cancer H460 cells. The binding phenomenon of SPBH was investigated by 1H NMR spectroscopy and HR-MS. Mass spectrometry analysis showed a 1:1 complex formation of SPBH with Al3+. The Job plot also confirmed its 1:1 interaction. This SPBH/Al3+ complex exhibited excellent fluorescence “turn-off” properties towards the F- anion. Thus, SPBH acts as a sequential fluorescence “Off-On-Off” probe. The limits of detection for Al3+ and F- were calculated from the titration curve and found to be 1.1 ¡Á 10-7 M and 1.47 ¡Á 10-6 M, respectively.

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Reference£º
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem