With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.42923-77-3,6-Methoxy-1,2,3,4-tetrahydroisoquinoline,as a common compound, the synthetic route is as follows.
General procedure: To a solution of secondary amine (2.0 mmol) in a mixture ofMeCN-THF (3.5 mL, 4:1) was added EDTA aqueous solution (2.8 mL,0.01 M) and NaHCO3 (0.84 g, 10.0 mmol) at 5 C. Oxone (1.29 g,2.1 mmol) was added portionwise over 2 h under vigorous stirringto maintain the temperature at 5 C. The resulting mixture wasstirred for another 20 min at 5 C, and then diluted with ethyl acetate(10 mL). The two phases were separated, and the aqueouslayer was extracted with ethyl acetate (3 10 mL). The combinedorganic layer was washed with brine, dried over Na2SO4 andconcentrated under reduced pressure. The crude product wasdirectly used in the next reaction without purification.
42923-77-3, 42923-77-3 6-Methoxy-1,2,3,4-tetrahydroisoquinoline 39356, atetrahydroisoquinoline compound, is more and more widely used in various fields.
Reference£º
Article; Liu, Gang; Song, Shanshan; Shu, Shiqi; Miao, Zehong; Zhang, Ao; Ding, Chunyong; European Journal of Medicinal Chemistry; vol. 103; (2015); p. 17 – 28;,
Tetrahydroisoquinoline – Wikipedia
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem