With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.22990-19-8,1-Phenyl-1,2,3,4-tetrahydroisoquinoline,as a common compound, the synthetic route is as follows.,22990-19-8
Optically active (S)-mandelic acid (0.5 equiv) was added to the solution of racemic compound 5 (1.0 equiv) in mixture of toluene and methanol solvents at room temperature. The resulting suspension was stirred at 80 C to make homogeneous reaction mixture. The stirring was continued with heating at 80 C until completion of reaction. It was found that after 30 min the reaction was completed. The solution was allowed to cool to room temperature. Mandelic acid resolves diastereomeric mixture to S-form of 5, which was filtered from the solution. The filter cake was washed once with toluene and air-dried to yield compound 6 (S-form) as a white solid in 47 % yield. Compound 6 was treated with 2 M Sodium hydroxide solution and the toluene was added. Two layers were separated. Toluene fraction was dried over anhydrous Na2SO4, concentrated and purified on silica gel column (eluted using mixture of hexane and ethyl acetate) to obtain pure S-isomer.
As the paragraph descriping shows that 22990-19-8 is playing an increasingly important role.
Reference£º
Article; Krishna Rao; Surendra Babu; Basaveswara Rao; Keshavi; Sundara Rao; Eswara Prasad; Murthy; Asian Journal of Chemistry; vol. 29; 5; (2017); p. 1035 – 1038;,
Tetrahydroisoquinoline – Wikipedia
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem