170097-67-3,2-(tert-Butoxycarbonyl)-1,2,3,4-tetrahydroisoquinoline-6-carboxylic acidbelongs to tetrahydroisoquinoline compound, is more and more widely used in various fields. and we look forward to future research findings.
170097-67-3,170097-67-3, 2-(tert-Butoxycarbonyl)-1,2,3,4-tetrahydroisoquinoline-6-carboxylic acid is a tetrahydroisoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Intermediate 9: 1 ,1-dimethylethyl 6-({ri-({5-chloro-2-r(2-methylpropyl)oxylphenyl}methyl)-5- ethyl-I H-pyrazol-S-yliaminolcarbonvD-S^-dihydro^d l-D-isoquinolinecarboxylate; To a solution of 1-({5-chloro-2-[(2-methylpropyl)oxy]phenyl}methyl)-5-ethyl-1 H-pyrazol-3- amine (Intermediate 7) (0.5 g, 1.62 mmol) in DMF (1 OmL) was added 2-{[(1 ,1- dimethylethyOoxylcarbonylJ-I ^.S^-tetrahydro-theta-isoquinolinecarboxylic acid (0.41 g, 0.9 eq.), HATU (0.74 g, 1.2 eq.) and DIEA (0.34 ml_,1.2 eq.) and the mixture was stirred at room temperature for 24 hours. The solvent was evaporated under reduced pressure and the residue was diluted with DCM. The organic phase was then washed with water and dried over Na2SO4, filtered and evaporated under reduced pressure. The residue was purified by flash column chromatography eluting with DCM/EtOAc: 95/5 to give the title compound as an oil (120 mg, 13%). LC/MS: m/z 567 (M+H)+ Rt: 4.23 min.
170097-67-3,2-(tert-Butoxycarbonyl)-1,2,3,4-tetrahydroisoquinoline-6-carboxylic acidbelongs to tetrahydroisoquinoline compound, is more and more widely used in various fields. and we look forward to future research findings.
Reference£º
Patent; SMITHKLINE BEECHAM CORPORATION; WO2008/74834; (2008); A2;,
Tetrahydroisoquinoline – Wikipedia
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem