With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.57196-62-0,6-Methoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride,as a common compound, the synthetic route is as follows.,57196-62-0
To a solution of 5-bromo-3-methyi- 1 -(p-toiyl)- 1H-pyrazoie- 4-carbonitrile (Intermediate Ii, 600 mg, 2.173 rnmol) in DM50 (20 ml) was added6-methoxy-i,2,3,4-teirahvdroisoquinoline hydrochloride (434 mg, 2.173 mmoi), Cs2CO3 (1416 mg, 4.35 rnmol) and Cul (414 ing. 2.173 inmol). The mixture was stirred at 140C for 18 h. The mixture was diluted with water (2×20 mL) and extracted with EtOAc (2 x 50 mL). The combined organic layers were dried over NaSO4, filtered and concentrated in vacuo. The residue was purified by silica gel column chromalography (PE:EtOAc=50 :1 to 30:1) to yieldthe title compound.
57196-62-0 6-Methoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride 2920335, atetrahydroisoquinoline compound, is more and more widely used in various fields.
Reference£º
Patent; MERCK SHARP & DOHME CORP.; ADAMS, Gregory, L.; COX, Jason, M.; DEBENHAM, John, S.; EDMONDSON, Scott; GILBERT, Eric, J.; GUO, Yan; JIANG, Yu; JOSIEN, Hubert; KIM, Hyunjin, M.; LAN, Ping; MIAO, Shouwu; PLUMMER, Christopher, W.; RAJAGOPALAN, Murali; SHAH, Unmesh; SUN, Zhongxiang; TRUONG, Quang, T.; UJJAINWALLA, Feroze; VELAZQUEZ, Francisco; VENKATRAMAN, Srikanth; SUZUKI, Takao; WANG, Nengxue; (182 pag.)WO2017/205193; (2017); A1;,
Tetrahydroisoquinoline – Wikipedia
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem