215798-19-9, 6-Bromo-1,2,3,4-tetrahydroisoquinoline hydrochloride is a tetrahydroisoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,215798-19-9
A suspension of 6-bromo-1,2,3,4-tetrahydroisoquinoline hydrochloride (CASNo.226942-29-6 , commercially available from Allichem LLC, 1 g, 4.02 mmol) and di-tert- butyl dicarbonate (1.87 ml, 8.05 mmol) in MeOH (10 ml) at room temperature under nitrogen was treated with triethylamine (2.80 ml, 20.12 mmol) and the resulting mixture was stirred at room temperature for 20 hours then concentrated in vacuo.The residue was partitioned between DCM and a saturated Na2CO3 aqueous solution and the two layers were separated using a phase separator cartridge. The organic phase was concentrated in vacuo and the residue loaded on a SCX column, eluting with MeOH. The combined methanolic fractions were concentrated in vacuo to give 1,1-dimethylethyl 6-bromo-3,4-dihydro-2(1H)-isoquinolinecarboxylate (1.215 g,97%) as a pale yellow gum.LCMS: retention time 1.38 min ; [M+H]+ = 314.02 (1 Br)
As the paragraph descriping shows that 215798-19-9 is playing an increasingly important role.
Reference£º
Patent; GLAXO GROUP LIMITED; SMETHURST, Christian, Alan, Paul; DEMONT, Emmanuel, Hubert; LIN, Xichen; REN, Feng; BAILEY, James, Matthew; WO2010/145202; (2010); A1;,
Tetrahydroisoquinoline – Wikipedia
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem