New Advances in Chemical Research in 2021. Chemistry is a science major with cience and engineering. The main research directions are chemical synthesis, and research on the structure and performance of functional materials.In a patent, 99365-69-2, name is 7-Nitro-1,2,3,4-tetrahydroisoquinoline hydrochloride, introducing its new discovery. Application In Synthesis of 7-Nitro-1,2,3,4-tetrahydroisoquinoline hydrochloride
The invention relates to a compound of a general formula (I):wherein A1 and A2 each mean a nitrogen atom or an optionally-substituted methine group; Ring B means a 5-memberedto 7-membered aliphatic ring, or a spiro or bicyclo ring formed from the aliphatic ring and any other 3-membered to 7-membered aliphatic ring; R1 means a hydrogen atom, or an optionally-substituted C1-C6 alkyl group, or an optionally-substituted aryl, aralkyl or heteroaryl group; R2 means an optionally-substituted aryl, aralkyl or heteroaryl group; and X means a group of =NH or =O, etc.Based on its excellent Wee1 kinase-inhibitory effect, the compound of the invention has cell growth-inhibitory effect and has an additive/synergistic effect with any other anticancer agent, and is therefore useful in the field of medicine.
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Reference：
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem