With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.99365-69-2,7-Nitro-1,2,3,4-tetrahydroisoquinoline hydrochloride,as a common compound, the synthetic route is as follows.
99365-69-2, Example 11: Synthesis of 3-[l-(3,4-dimethoxy-benzoyl)-pyrrolidin-2-yl]-N-(l,2,3,4- tetrah dro-isoquinolin-7-yl)-benzamide trifluoroacetic acid (Compound 45).; To a solution of 7-nitro-l,2,3,4-tetrahydroisoquinoline hydrochloride (11.0 g, 51.25 mmol) in EtOAc (150 mL) at 0 ¡ãC in an ice bath add a solution of K2C03 (15.65 g, 113.25 mmol) in water (150 mL) followed by benzyl chloroformate (8.37 mL, 56.37 mmol) and vigorously stir the reaction at room temperature for 24 h. Separate the layers and extract the aqeuous with more EtOAc (150 mL). Wash the organics with sat.NaHC03 (200 mL), sat. NH4C1 (200 mL) and water (200 mL), then dry (Na2S04).Concentrate in vacuo to give 14.70 g of 7-nitro-3,4-dihydro-lH-isoquinoline-2- carboxylic acid benzyl ester as an oil which partially crystallizes.
As the paragraph descriping shows that 99365-69-2 is playing an increasingly important role.
Reference£º
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; GINN, John David; MARSHALL, Daniel Richard; SIBLEY, Robert; SORCEK, Ronald John; YOUNG, Erick Richard Roush; ZHANG, Yunlong; WO2012/6202; (2012); A1;,
Tetrahydroisoquinoline – Wikipedia
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem