With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.99365-69-2,7-Nitro-1,2,3,4-tetrahydroisoquinoline hydrochloride,as a common compound, the synthetic route is as follows.,99365-69-2
Sodium cyanoborohydride (5.9 g) was added to a methanol (450 mL) solution of the compound (10 g) obtained in the above reaction 1), aqueous 37 percent formaldehyde solution (10.4 mL) and acetic acid (4 mL), and stirred at 50¡ãC for 15 hours. The precipitated solid was collected through filtration, and washed with methanol. The resulting crude product was purified through basic silica gel column chromatography (hexane/ethyl acetate) to give the entitled compound as a colorless solid (8.7 g). 1H-NMR (CDCl3) delta: 7.99 (1H, dd, J = 8.5, 2.0 Hz), 7.92 (1H, d, J = 2.0 Hz), 7.26 (1H, d, J = 8.5 Hz), 3.65 (2H, s), 3.01 (2H, t, J = 5.9 Hz), 2.73 (2H, t, J = 5.9 Hz), 2.49 (3H, s). ESI-MS Found: m/z[M+H] 193.
As the paragraph descriping shows that 99365-69-2 is playing an increasingly important role.
Reference£º
Patent; Banyu Pharmaceutical Co., Ltd.; EP2213673; (2010); A1;,
Tetrahydroisoquinoline – Wikipedia
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem