With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.42923-79-5,7-Nitro-1,2,3,4-tetrahydroisoquinoline,as a common compound, the synthetic route is as follows.,42923-79-5
To a suspension of the product from Step A (12 g, 58 MMOL), and pyridine (23.7 mL, 293 mmol) in anhydrous CHZCIZ (50 mL) cooled at 0 C was added in a dropwise manner trifluoroacetic anhydride (12 ML, 87 MMOL), and the resulting mixture was stirred at room temperature for 18 h. The reaction mixture was poured onto ice (500 g) and extracted with CH2CI2 (4 x 150 mL). The combined CH2CI2 layers were washed with 1 N HCl (4 x 100 ML), saturated NaCl (100 mL), dried over NA2SO4, filtered and evaporated IN VACUO to give the product (15.92 g, 89 %) ; H NMR 500MHZ (CDCl3) 8 = 3.07 (2H, m), 3.91 and 3.94 (2H, t, J = 6. 2 HZ), 4. 85 and 4.88 (2H, s), 7.36 (1H, dd, J = 8.7 and 11.9 Hz), 8.07 (1H, dd, J=2. 3AND 8.5 Hz), 8.01-8. 08 (2H m).
42923-79-5 7-Nitro-1,2,3,4-tetrahydroisoquinoline 6424833, atetrahydroisoquinoline compound, is more and more widely used in various fields.
Reference£º
Patent; MERCK & CO., INC.; MERCK SHARP & DOHME LIMITED; WO2004/94371; (2004); A2;,
Tetrahydroisoquinoline – Wikipedia
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem