82771-60-6, 7-Chloro-1,2,3,4-tetrahydroisoquinoline is a tetrahydroisoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,82771-60-6
To a mixture of 7-chloro-1, 2, 3, 4-tetrahydroisoquinoline (20 mg, 0.12 mmol) , 2- (5-amino-2- (furan-2-yl) -7H-pyrazolo [4, 3-e] [1, 2, 4] triazolo [1, 5-c] pyrimidin-7-yl) -2-phenylacetic acid (40 mg, 0.11 mmol) , DIPEA (100 mg, 0.77 mmol) in DMF (1 mL) was added HATU (50 mg, 0.13 mmol) at rt and the mixture was stirred at rt for 16 hrs. 20 mL of EA was added and the mixture was washed with brine (10 mL x 3) , dried over Na2SO4and concentrated. The resulting residue was purified by prep-TLC (PE/EA = 1: 2) to give the title product (16.0 mg, yield: 28%) .1H NMR (400 MHz, DMSO-d6) delta 8.24 -8.03 (m, 3H) , 7.95 (s, 1H) , 7.50 -7.26 (m, 6H) , 7.24 (s, 1H) , 7.21 -7.03 (m, 2H) , 6.95 -6.88 (m, 1H) , 6.74 (s, 1H) , 4.78 -4.33 (m, 2H) , 3.80 -3.49 (m, 2H) , 2.84 -2.27 (m, 2H) . MS: M/e 525 (M+1)+.
The synthetic route of 82771-60-6 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; BEIGENE, LTD.; ZHANG, Guoliang; SUN, Hanzi; ZHOU, Changyou; (253 pag.)WO2020/20097; (2020); A1;,
Tetrahydroisoquinoline – Wikipedia
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem