As a common heterocyclic compound, it belongs to tetrahydroisoquinoline compound, name is Methyl 1,2,3,4-tetrahydroisoquinoline-3-carboxylate hydrochloride, and cas is 57060-88-5, its synthesis route is as follows.,57060-88-5
To a stirred solution of methyl 1,2,3,4-tetrahydro-3-isoquinolinecarboxylate hydrochloride (4.5 g) in dichloromethane (150 mL) was added triethylamine (6.1 mL) and 3-methoxy-4-tert-butylbenzoyl chloride (5.0 g) and the resultant mixture was stirred at room temperature for 18 hours. The reaction mixture was washed with saturated aqueous sodium bicarbonate solution and was then dried and evaporated to gum. This material was purified using chromatography over silica gel eluting with ethyl acetate/cyclohexane (15:85 v/v). Appropriate fractions were combined and evaporated to give the title compound. MS calcd for (C23H27NO4 + H)+: 382 MS found (electrospray) (M+H)+ = 382.
With the complex challenges of chemical substances, we look forward to future research findings about 57060-88-5,belong tetrahydroisoquinoline compound
Reference£º
Patent; GLAXO GROUP LIMITED; WO2004/96774; (2004); A1;,
Tetrahydroisoquinoline – Wikipedia
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem