A common heterocyclic compound, the tetrahydroisoquinoline compound, name is 7-Nitro-1,2,3,4-tetrahydroisoquinoline,cas is 42923-79-5, mainly used in chemical industry, its synthesis route is as follows.
The mixture of 7-nitro-l,2,3,4-tetrahydroisoquinoline and 6-nitro-l,2,3,4- tetrahydroisoquinoline (1.Og, 5.6mmol, 1 equiv) was dissolved in a mixture of aqueous ammonium chloride [(2.4g, 44.8mmol, 8 equiv) in 6 ml of water] and ethanol (4ml). Iron powder (1.3g, 23.3mmol, 4 equiv) was added and the reaction mixture was stirred at 60C for 24hrs. The mixture was cooled down to room temperature and then filtered throughCelite. The filter cake was washed with ethanol (50ml). The orange solution was filtered again to remove any inorganics, concentrated in vacuum and azeotroped with toluene. The residue was stirred in ethanol (50ml) at 40C and filtered. The filtrate was concentrated to give the title mixture as a yellow solid ( 0.85g, 100%).1H NMR (MeOD, 400MHz) delta= 6.95 (m, IH), 6.66 (m, IH), 6.63 (m, IH), 4.2 (m, 2H), 3.4 (m, 2H), 3.0 (m, 2H).
42923-79-5, As the rapid development of chemical substances, we look forward to future research findings about 42923-79-5
Reference£º
Patent; CELLZOME AG; WO2009/62658; (2009); A1;,
Tetrahydroisoquinoline – Wikipedia
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem