The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: Picolinamide( cas:1452-77-3 ) is researched.Name: Picolinamide.Lo, Yi-Hsuan; Chang, Ting-Yu; Chen, Chuan-Lin; Lin, Ming-Hsien; Wang, Hsin-Ell; Chang, Chi-Wei; Liu, Ren-Shyan; Wu, Chun-Yi published the article 《Development of radiofluorinated nicotinamide/picolinamide derivatives as diagnostic probes for the detection of melanoma》 about this compound( cas:1452-77-3 ) in International Journal of Molecular Sciences. Keywords: radiofluorinated nicotinamide picolinamide derivative diagnostic probe melanoma detection; melanin-targeting probe; melanoma; radiofluorinated nicotinamide–benzamide derivative (18F-FNABZA); radiofluorinated picolinamide–benzamide derivative (18F-FPABZA). Let’s learn more about this compound (cas:1452-77-3).
Regarding the increased incidence and high mortality rate of malignant melanoma, practical early-detection methods are essential to improve patients′ clin. outcomes. In this study, we successfully prepared novel picolinamide-benzamide (18F-FPABZA) and nicotinamide-benzamide (18F-FNABZA) conjugates and determined their biol. characteristics. The radiochem. yields of 18F-FPABZA and 18F-FNABZA were 26 ± 5% and 1 ± 0.5%, resp. 18F-FPABZA was more lipophilic (log P = 1.48) than 18F-FNABZA (log P = 0.68). The cellular uptake of 18F-FPABZA in melanotic B16F10 cells was relatively higher than that of 18F-FNABZA at 15 min post-incubation. However, both radiotracers did not retain in amelanotic A375 cells. The tumor-to-muscle ratios of 18F-FPABZA-injected B16F10 tumor-bearing mice increased from 7.6 ± 0.4 at 15 min post-injection (p.i.) to 27.5 ± 16.6 at 3 h p.i., while those administered with 18F-FNABZA did not show a similarly dramatic increase throughout the exptl. period. The results obtained from biodistribution studies were consistent with those derived from microPET imaging. This study demonstrated that 18F-FPABZA is a promising melanin-targeting positron emission tomog. (PET) probe for melanotic melanoma.
In some applications, this compound(1452-77-3)Name: Picolinamide is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.
Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem