Computed Properties of C10H10Cl2N2Pt. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: cis-Dichlorobis(pyridine)platinum(II), is researched, Molecular C10H10Cl2N2Pt, CAS is 15227-42-6, about Binding of antitumor platinum compound to cells as influenced by physical factors and pharmacologically active agents. Author is Gale, Glen R.; Morris, Carl R.; Atkins, Loretta M.; Smith, Alayne B..
Tritiated cis-dichloro(dipyridine)platinum(II) (I) [15227-42-6] bound to intact Ehrlich ascites tumor cells at 37.deg. in vitro and remained associated with the acid-insoluble fraction of the cells. The extent of binding was also increased with increasing hydrogen ion [1333-74-0] concentration in the medium. The binding was enhanced markedly at 60.deg. and the maximum number of binding sites/cell was .sim.7 billion at this temperature Of 49 chems. and drugs tested, none decreased appreciably the rate and extent of binding, whereas certain heavy metals, and compounds that compromise membrane permeability enhanced the binding. Human and bovine lymphocytes had similar binding characteristics, but bound much more I/unit of cell volume.
If you want to learn more about this compound(cis-Dichlorobis(pyridine)platinum(II))Computed Properties of C10H10Cl2N2Pt, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(15227-42-6).
Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem