The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: D-Alanine methylamide hydrochloride( cas:61302-99-6 ) is researched.Formula: C4H11ClN2O.Crisma, M.; Fasman, G. D.; Balaram, H.; Balaram, P. published the article 《Peptide models for β-turns. A circular dichroism study》 about this compound( cas:61302-99-6 ) in International Journal of Peptide & Protein Research. Keywords: peptide beta turn conformation CD. Let’s learn more about this compound (cas:61302-99-6).
The CD spectra of β-turn model peptides PhCH2O2C-Aib-Pro-Aib-Pro-OMe (I, Aib = NHCMe2CO), Piv-Pro-Aib-NHMe (II, Piv = Me3CCO), Piv-Pro-D-Ala-NHMe (III), and Piv-Pro-Val-NHMe (IV) were examined in methanol, hexafluoroisopropanol, and cyclohexane. Type I and Type II β-turns were observed for I and II, resp., in the solid state, while the Pro-D-Ala sequence adopts a Type II β-turn in a related peptide crystal structure. A class C spectrum was observed for I in various solvents, suggesting a variant of a Type I (III) structure. The Type II β-turn is characterized by a CD spectrum having two pos. CD bands at ∼230 nm and ∼202 nm, a feature observed in III in cyclohexane and methanol and for II in methanol. II exhibits solvent-dependent CD spectra, which may be rationalized by considering Type II, III and V reverse turn structures. IV adopts non-β-turn structures in polar solvents, but exhibits a class B spectrum in cyclohexane suggesting a population of Type I β-turns.
If you want to learn more about this compound(D-Alanine methylamide hydrochloride)Formula: C4H11ClN2O, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(61302-99-6).
Reference:
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