In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Bis(N-picolinamido)cobalt(II) Complexes Display Antifungal Activity toward Candida albicans and Aspergillus fumigatus, published in 2021-10-15, which mentions a compound: 1452-77-3, mainly applied to Candida Aspergillus bis N picolinamido cobalt II antifungal; Aspergillus fumigatus; Bioinorganic Chemistry; Candida albicans; Cobalt Complexes; Picolinamide ligands, Recommanded Product: 1452-77-3.
This report highlights the synthesis and characterization of ten new bis(N-picolinamido)cobalt(II) complexes of the type [(L)2CoX2]0/2+, whereby L=N-picolinamide ligand and X=diisothiocyanato (-NCS), dichlorido (-Cl) or diaqua (-OH2) ligands. Single crystal X-ray (SC-XRD) anal. for nine of the structures are reported and confirm the picolinamide ligand is bound to the Co(II) center through a neutral N,O binding mode. With the addition of powder X-ray diffraction (PXRD), we have confirmed the cis and trans ligand arrangements of each complex. All complexes were screened against several fungal species and show increased antifungal activity. Notably, these complexes had significant activity against strains of Candida albicans and Aspergillus fumigatus, with several compounds exhibiting growth inhibition of >80 %, and onecompound inhibiting Aspergillus fumigatus hyphal growth by >90 %. Conversely, no antifungal activity was exhibited toward Cryptococcus neoformans and no cytotoxicity towards mammalian cell lines.
There is still a lot of research devoted to this compound(SMILES：O=C(N)C1=NC=CC=C1)Recommanded Product: 1452-77-3, and with the development of science, more effects of this compound(1452-77-3) can be discovered.
Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem