The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: cis-Dichlorobis(pyridine)platinum(II)( cas:15227-42-6 ) is researched.Related Products of 15227-42-6.Howle, Jerry A.; Gale, Glen R.; Smith, Alayne B. published the article 《Proposed mode of action of antitumor platinum compounds based upon studies with cis-dichloro([G-3H]-dipyridine)platinum(II)》 about this compound( cas:15227-42-6 ) in Biochemical Pharmacology. Keywords: chloropyridine platinum tumor; DNA dichlorodipyridine platinum; erythrocyte dichlorodipyridine platinum; RNA dichlorodipyridine platinum. Let’s learn more about this compound (cas:15227-42-6).
The antitumor and antimitotic action of the pyridine-tritiated square-planar Pt complex cis-dichloro(dipyridine)platinum(II) (I) [15227-42-6] seems to depend on the dissociation of 1 or both chlorine atoms from the platinum atom. The resulting cationic, aquated species subsequently forms a bond with nucleic acid. I associate avidly with calf thymus DNA, high mol. weight yeast RNA, and bacterial and yeast tRNA, but not with bovine serum albumin, dextran, or purified erythrocyte membranes. Dialysis of the Pt-nucleic acid complexes in distilled water or NaCl results in loss of a portion of the original radioactivity. The Pt-DNA bond is resistant to dissociation by solubilization in alkali followed by trichloroacetic acid (TCA) precipitation Bonding of I to DNA in vitro is inhibited by NaCl; however, prior alkylation of the DNA with nitrogen mustard does not influence its subsequent bonding with I. I associate with intact Ehrlich ascites tumor cells in vitro at 2.deg. and 37.deg. and resists dissociation by washing with saline or TCA as well as solubilization in alkali followed by re-precipitation with TCA.
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Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem