So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Evora, Antonio O. L.; Castro, Ricardo A. E.; Maria, Teresa M. R.; Ramos Silva, M.; Canotilho, Joao; Eusebio, M. Ermelinda S. researched the compound: Picolinamide( cas:1452-77-3 ).Computed Properties of C6H6N2O.They published the article 《Lamotrigine: Design and synthesis of new multicomponent solid forms》 about this compound( cas:1452-77-3 ) in European Journal of Pharmaceutical Sciences. Keywords: lamotrigine multicomponent solid forms; Co-crystals and salts; Diflunisal; Lamotrigine; Pyridinecarboxamides; Stability assay; Xanthines. We’ll tell you more about this compound (cas:1452-77-3).
In this work, a crystal engineering and thermodn. based approach has been used aiming at contributing to a deeper knowledge of lamotrigine multicomponent solid forms. Two types of co-mols. have been chosen that can give rise to co-crystals with lamotrigine through different supramol. heterosynthons: the xanthines, theophylline and caffeine, and the three isomeric pyridinecarboxamides. Association with diflunisal, which may result in a salt, was also investigated. Mechanochem., differential scanning calorimetry, thermogravimetry, X-ray powder and single crystal diffraction, IR spectroscopy were the methods used. For all the systems, exploratory neat mechanochem. experiments, carried out on lamotrigine + co-mol. binary mixtures of different compositions, were not successful in promoting association From differential scanning calorimetry data and the binary solid-liquid phase diagrams, co-crystals/salts were identified as well as their resp. stoichiometry, and a methodol. of synthesis was established. For pyridinecarboxamides, mol. recognition is dependent on the position of the amide group in the pyridine ring: co-crystallization did not occur with picolinamide co-former. Both xanthines form co-crystals with lamotrigine, (1:1) with theophylline and (2:1) lamotrigine:caffeine. Addnl., the crystalline structure of a lamotrigine:theophylline 1:1 monohydrate was solved. The (1:1) lamotrigine:theophylline co-crystal converts to this monohydrate in accelerated stability tests. A (1:1) lamotrigine:diflunisal salt was identified, which proved to be stable in accelerated stability assays.
In addition to the literature in the link below, there is a lot of literature about this compound(Picolinamide)Computed Properties of C6H6N2O, illustrating the importance and wide applicability of this compound(1452-77-3).
Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem