The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: Picolinamide(SMILESS: O=C(N)C1=NC=CC=C1,cas:1452-77-3) is researched.SDS of cas: 693-67-4. The article 《Effect of nicotinamide on the flagellar detachment and regeneration of Euglena》 in relation to this compound, is published in Bitamin. Let’s take a look at the latest research on this compound (cas:1452-77-3).
Euglena is capable of growth under various variety of nutritional and environmental conditions. Euglena is possible to grow under diverse culture conditions with and without light illumination, namely under both heterotrophic and photoautotrophic conditions. Euglena can synthesize most of vitamins and biofactors except for the exception, such as vitamin B1 and B12. In the present study, the effects of nicotinamide and its analogs on the flagellar detachment of Euglena were investigated using nicotinamide and the 12 kinds of structural analogs (nicotinic acid, pyrazine, pyrazine-2-carboxylic acid, 2-picolinamide, methylnicotinate, N-methylnicotinamide, 3-methylpyridine, pyridine-3-sulfate, pyridoxine, pyridoxal, pyridoxamine, isonicotinic acid hydrazide), NAD+, and NADP+. Among these compounds, nicotinamide, nicotinic acid, pyrazine-2-carboxylic acid, methylnicotinate, 2-picolinamide, and N-methylnicotinamide caused of the flagellar detachment and then cell division stopped. It was also found that nicotinamide added to Euglena cell was dilute with water and culture medium, cell division occurred and then flagella were regenerated after 24h, resulting in onset euglenoid exercise. The electrophoresis of the detached flagellar proteins reveled that the protein resembled tublin (55 kDa) and paraflagella rod 2 (69 KDa).
This literature about this compound(1452-77-3)Application In Synthesis of Picolinamidehas given us a lot of inspiration, and I hope that the research on this compound(Picolinamide) can be further advanced. Maybe we can get more compounds in a similar way.
Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem