Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: Picolinamide, is researched, Molecular C6H6N2O, CAS is 1452-77-3, about Bis-heteroleptic ruthenium(II) complex with 2-picolinamide: Synthesis, crystal structures, and spectroscopic study for anion recognition using the amide group.Computed Properties of C6H6N2O.
Cis-[Ru(bpy)2(OH2)2](OTf)2 (1·(OTf)2; OTf- = CF3SO3-) was reacted with 2-picolinamide (H2pia) in EtOH to form bis-heteroleptic complex [Ru(bpy)2(H2pia)]X2 (2·X2; X- = OTf- or Cl-). Crystal structures of 2·X2 revealed that H2pia was coordinated to Ru(II) through N of pyridyl group and O of amide group to form the N,O-coordination, and acted as a neutral ligand. Bond distances around the amide group and 1H NMR study for 22+ suggested that π-electron on the carbonyl group was delocalized to the whole amide group. Adding F- to the acetonitrile solution of 2·(OTf)2 changed the red solution to dark-red due to the transportation of π-electron on the amide group by the bound F- to the amide H. Absorption and 1H NMR spectroscopies revealed that the NH2 of 22+ undergoes selective two-step adduct reaction with F-: the H close to pyridyl group of H2pia first formed a 1:1 adduct (mono-F-adduct-22+), followed by the other H forming the 1:2 adduct (di-F-adduct-22+). Adding excess Li(OTf) to these F-adduct-22+ solutions changed the dark-red solution back to red, suggesting that the adducted F- was removed by Li+ to form 22+ and LiF.
This literature about this compound(1452-77-3)Computed Properties of C6H6N2Ohas given us a lot of inspiration, and I hope that the research on this compound(Picolinamide) can be further advanced. Maybe we can get more compounds in a similar way.
Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem