The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: Picolinamide, is researched, Molecular C6H6N2O, CAS is 1452-77-3, about Synthesis of N-(6-[18F]Fluoropyridin-3-yl)glycine as a potential renal PET agent, the main research direction is fluorine pyridin glycine picolinamide bromine nicotin hydrolysis plasmaprotein binding; N-(6-[(18)F]Fluoropyridin-3-yl)glycine; PET; Renal PET radiopharmaceutical; Renogram.Application In Synthesis of Picolinamide.
Given the requirements of high sensitivity and spatial resolution, the development of new positron emission tomog. (PET) agents is required for PET renog. The objective of this study was to investigate a new fluorine-18 labeled hippurate analog of picolinamide, N-(6-[18F]Fluoropyridin-3-yl)glycine, as a new renal PET agent for evaluating renal function. N-(6-[18F]Fluoropyridin-3-yl)glycine was prepared via a two-step reaction, including the nucleophilic substitution reaction of Br with 18F using Me 2-(6-bromonicotinamido)acetate as a precursor followed the hydrolysis with sodium hydroxide and purification by preparative-HPLC. The in vitro and in vivo stability were determined using HPLC, and the plasma protein binding (PPB) and erythrocyte uptake of N-(6-[18F]Fluoropyridin-3-yl)glycine were determined using blood collected from healthy rats at 5 min post-injection. Biodistribution and dynamic micro-PET/CT imaging studies were conducted in healthy rats. N-(6-[18F]Fluoropyridin-3-yl)glycine demonstrated good stability both in vitro and in vivo. The results of the biodistribution and dynamic micro-PET/CT imaging studies in normal rats indicated that N-(6-[18F]Fluoropyridin-3-yl)glycine was rapidly and exclusively excreted via the renal-urinary pathway. N-(6-[18F]Fluoropyridin-3-yl)glycine is has been shown to be a promising renal PET agent and warrants further evaluation of renal function.
As far as I know, this compound(1452-77-3)Application In Synthesis of Picolinamide can be applied in many ways, which is helpful for the development of experiments. Therefore many people are doing relevant researches.
Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem